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Genomics and Clinical Diagnostics
Edited by
David Whitehouse;
David Whitehouse
University of Hertfordshire, UK
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Ralph Rapley
Ralph Rapley
University of Hertfordshire, UK
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Hardback ISBN:
978-1-78262-821-7
EPUB ISBN:
978-1-78801-680-3
PDF ISBN:
978-1-83916-884-0
Special Collection:
RSC eTextbook Collection
Product Type:
Textbooks
No. of Pages:
574
Publication date:
29 Jan 2019
Book Chapter
7: Comparative Genomics and the Improved Diagnosis of Trypanosomiasis and Visceral Leishmaniasis†
By
Tapan Bhattacharyya
;
Tapan Bhattacharyya
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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Tegwen Marlais
;
Tegwen Marlais
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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Bruno Hinckel
;
Bruno Hinckel
Coris BioConcept
Gembloux
Belgium
University of Antwerp
Belgium
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David Mateus
;
David Mateus
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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Hai Le
;
Hai Le
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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Niamh Murphy
;
Niamh Murphy
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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Noah Fongwen
;
Noah Fongwen
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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Matthew Yeo
;
Matthew Yeo
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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Pascal Mertens
;
Pascal Mertens
Coris BioConcept
Gembloux
Belgium
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Michael Miles
Michael Miles
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine
London
UK
tapan.bhattacharyya@lshtm.ac.uk michael.miles@lshtm.ac.uk
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-
Published:29 Jan 2019
-
Special Collection: RSC eTextbook CollectionProduct Type: Textbooks
Page range:
186 - 211
Citation
T. Bhattacharyya, T. Marlais, B. Hinckel, D. Mateus, H. Le, N. Murphy, ... M. Miles, in Genomics and Clinical Diagnostics, ed. D. Whitehouse and R. Rapley, The Royal Society of Chemistry, 2019, pp. 186-211.
Download citation file:
This chapter focuses on trypanosomiasis and leishmaniasis and demonstrates how comparative genetic and genomic analyses have informed and will continue to empower diagnostics discovery, and have led to the development of low-cost, point-of-care, rapid diagnostic tests, with both clinical and research applications. Also highlighted is the still underexploited potential of a systematic combined ‘omics’ approach to both the identification of candidate vaccines and production of prototype diagnostics.
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