Genomics and Clinical Diagnostics
7: Comparative Genomics and the Improved Diagnosis of Trypanosomiasis and Visceral Leishmaniasis†
Published:29 Jan 2019
T. Bhattacharyya, T. Marlais, B. Hinckel, D. Mateus, H. Le, N. Murphy, ... M. Miles, in Genomics and Clinical Diagnostics, ed. D. Whitehouse and R. Rapley, The Royal Society of Chemistry, 2019, pp. 186-211.
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This chapter focuses on trypanosomiasis and leishmaniasis and demonstrates how comparative genetic and genomic analyses have informed and will continue to empower diagnostics discovery, and have led to the development of low-cost, point-of-care, rapid diagnostic tests, with both clinical and research applications. Also highlighted is the still underexploited potential of a systematic combined ‘omics’ approach to both the identification of candidate vaccines and production of prototype diagnostics.