CHAPTER 13: Role of Cyclobutane Pyrimidine Dimers in Non-genetic Related Responses in Skin
Published:06 Dec 2021
Special Collection: 2021 ebook collection
A. R. Young and K. P. Lawrence, in DNA Photodamage: From Light Absorption to Cellular Responses and Skin Cancer, ed. R. Improta and T. Douki, The Royal Society of Chemistry, 2021, pp. 291-306.
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Solar ultraviolet radiation (UVR) induces cutaneous DNA damage, the most important type of which is the cyclobutane pyrimidine dimer (CPD). This lesion may result in mutation that initiates skin cancer. However, there is strong evidence that the CPD induces many other responses, including erythema (sunburn), pigmentation and the release of cytokines, which are inflammatory and immunoregulatory mediators. There is compelling evidence that the CPD is the trigger for the downregulation of immunity that may lead to skin cancer. Thus, the CPD plays a dual role in photocarcinogenesis. Removal of the CPD, whether by endogenous repair mechanisms or experimental manipulation, abrogates many of the adverse effects of solar UVR exposure.