Skip to Main Content
Skip Nav Destination

Solar ultraviolet radiation (UVR) induces cutaneous DNA damage, the most important type of which is the cyclobutane pyrimidine dimer (CPD). This lesion may result in mutation that initiates skin cancer. However, there is strong evidence that the CPD induces many other responses, including erythema (sunburn), pigmentation and the release of cytokines, which are inflammatory and immunoregulatory mediators. There is compelling evidence that the CPD is the trigger for the downregulation of immunity that may lead to skin cancer. Thus, the CPD plays a dual role in photocarcinogenesis. Removal of the CPD, whether by endogenous repair mechanisms or experimental manipulation, abrogates many of the adverse effects of solar UVR exposure.

You do not currently have access to this chapter, but see below options to check access via your institution or sign in to purchase.
Don't already have an account? Register
Close Modal

or Create an Account

Close Modal
Close Modal