CHAPTER 12: Repair of UV-induced DNA Damage and RNA: A Helpful Interplay for Genome Surveillance
Published:06 Dec 2021
Special Collection: 2021 ebook collection
Ultraviolet (UV) irradiation induces, directly and indirectly, a wide range of DNA lesions (photolesions, DNA double-strand breaks) that interfere with genome integrity and transcriptional programs. Therefore, it is crucial to understand how genome and transcriptome cooperate to cope with these DNA damages. The combined expertise of DNA and RNA biologists deciphered unexpected interplays between mechanisms involving non-coding RNA and DNA repair pathways. Due to their sessile lifestyle, plants evolved sophisticated mechanisms to maintain genome integrity. Several studies uncovered the involvement of different populations of non-coding RNA in the repair of photodamage and DNA double-strand breaks. This chapter will highlight the different pathways involving small RNA during the excision repair of UV-induced DNA lesions.