Chapter 13: Macrocyclic Lactone Endectocides

The macrocyclic lactone endectocides such as ivermectin, abamectin, selamectin and moxidectin have revolutionized the treatment of parasitic diseases in animals, being active against internal and external parasites. Ivermectin was introduced into veterinary medicine in the 1980s and since that time a number of related compounds have been introduced. In the treatment of internal parasites they complement the use of levamisole and the benzimidazoles, but in recent years they have found utility in treating external insect parasites. These agents show very low levels of toxicity under most circumstances. However, they are neurotoxic particularly in subpopulations of animals with mutations in the MDR1 gene. Toxicity may be also seen during off-label use, possibly because the doses used have been extrapolated from use in other animals. Regardless of these considerations, the macrocyclic lactone endectocides are extremely effective and safe drugs in the treatment of parasitic diseases of animals.