Skip Nav Destination
Drug Discovery
Polyamine Drug Discovery
Edited by
Patrick Woster;
Patrick Woster
Medical University of South Carolina, USA
Search for other works by this author on:
Robert Casero
Robert Casero
Johns Hopkins University, USA
Search for other works by this author on:
Hardback ISBN:
978-1-84973-190-4
PDF ISBN:
978-1-84973-309-0
Special Collection:
2011 ebook collection
,
2011 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery Series
No. of Pages:
302
Published online:
07 Nov 2011
Published in print:
30 Nov 2011
About this book
Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field.
Polyamine Drug Discovery, The Royal Society of Chemistry, 2011.
Download citation file:
Digital access
$186.00
Print format
Polyamine Drug Discovery
$186.00
Table of contents
-
Polyamine Drug Discovery: Synthetic Approaches to Therapeutic Modulators of Polyamine Metabolismp1-27ByPatrick M. WosterPatrick M. WosterDepartment of Pharmaceutical and Biomedical SciencesMedical University of South Carolina, 70 President St., Charleston, SC 29425USASearch for other works by this author on:
-
Chapter 2: Structural Biology in Polyamine Drug Discoveryp28-49ByShridhar Bale;Shridhar BaleDepartment of Chemistry and Chemical Biology120 Baker Lab, CornellUniversity, Ithaca, NY 14853-1301USASearch for other works by this author on:Steven E. Ealick*Steven E. Ealick*Department of Chemistry and Chemical Biology120 Baker Lab, CornellUniversity, Ithaca, NY 14853-1301USASearch for other works by this author on:
-
Chapter 3: Antiparasitic Drug Discovery for the Polyamine Pathwayp50-77ByNigel Yarlett;Nigel YarlettHaskins Laboratories and Department of Chemistry and Physical SciencesPace University, New York, NY 10038USASearch for other works by this author on:Mary MoradaMary MoradaHaskins Laboratories and Department of Chemistry and Physical SciencesPace University, New York, NY 10038USASearch for other works by this author on:
-
Chapter 4: Inhibitors of Polyamine Biosynthetic Enzymesp78-103ByAnthony E. PeggAnthony E. PeggDepartment of Cellular and Molecular PhysiologyMilton S. Hershey Medical Center, Pennsylvania State University College of Medicine, PA17033USASearch for other works by this author on:
-
Chapter 5: Symmetrical- and Unsymmetrical Terminally Alkylated Polyaminesp104-134ByPatrick M. Woster;Patrick M. WosterDepartment of Pharmaceutical and Biomedical SciencesMedical University of South Carolina, 70 President St., Charleston, SC 29425USASearch for other works by this author on:Robert A. Casero, JrRobert A. Casero, JrThe Sidney Kimmel Comprehensive Cancer CenterBunting-Blaustein Cancer Research Building, Johns Hopkins University, 1650 Orleans St., Baltimore, MD 21231USASearch for other works by this author on:
-
Chapter 6: Targeting the Polyamine Catabolic Enzymes Spermine Oxidase, N1-Acetylpolyamine Oxidase and Spermidine/Spermine N1-Acetyltransferasep135-161ByAndrew C. Goodwin;Andrew C. GoodwinThe Sidney Kimmel Comprehensive Cancer CenterThe Johns Hopkins School of Medicine, Bunting/Blaustein Cancer Research Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231USASearch for other works by this author on:Tracy R. Murray-Stewart;Tracy R. Murray-StewartThe Sidney Kimmel Comprehensive Cancer CenterThe Johns Hopkins School of Medicine, Bunting/Blaustein Cancer Research Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231USASearch for other works by this author on:Robert A. Casero, JrRobert A. Casero, JrThe Sidney Kimmel Comprehensive Cancer CenterThe Johns Hopkins School of Medicine, Bunting/Blaustein Cancer Research Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231USASearch for other works by this author on:
-
Chapter 7: Design of Polyamine Transport Inhibitors as Therapeuticsp162-190ByOtto Phanstiel IV;Otto Phanstiel IVCollege of MedicineHealth Sciences Campus at Lake Nona, University of Central Florida, 6850 Lake Nona Blvd., Orlando, FL 32827-7408USASearch for other works by this author on:Jennifer Julian ArcherJennifer Julian ArcherCollege of MedicineHealth Sciences Campus at Lake Nona, University of Central Florida, 6850 Lake Nona Blvd., Orlando, FL 32827-7408USASearch for other works by this author on:
-
Chapter 8: Non-Covalent Polynuclear Platinum Compounds as Polyamine Analogsp191-204ByYun Qu;Yun QuDepartment of ChemistryVirginia Commonwealth University, Richmond, VA 23284-2006AustraliaSearch for other works by this author on:Joseph J. Moniodis;Joseph J. MoniodisChemistry M313School of Biomedical, Biomolecular & Chemical Sciences, University of Western Australia, Crawley, WA 6009AustraliaSearch for other works by this author on:Amanda L. Harris;Amanda L. HarrisDepartment of ChemistryVirginia Commonwealth University, Richmond, VA 23284-2006AustraliaSearch for other works by this author on:Xiaohong Yang;Xiaohong YangDepartment of ChemistryVirginia Commonwealth University, Richmond, VA 23284-2006AustraliaSearch for other works by this author on:Alex Hegmans;Alex HegmansDepartment of ChemistryVirginia Commonwealth University, Richmond, VA 23284-2006AustraliaSearch for other works by this author on:Lawrence F. Povirk;Lawrence F. PovirkDepartment of Pharmacology380A Goodwin Laboratory, Massey Cancer Center, Virginia Commonwealth University, 401 College St., Richmond, VA 23298-0035USASearch for other works by this author on:Susan J. Berners-Price;Susan J. Berners-PriceChemistry M313School of Biomedical, Biomolecular & Chemical Sciences, University of Western Australia, Crawley, WA 6009AustraliaInstitute of GlycomicsGriffith University, Gold Coast Campus, Qld. 4222AustraliaSearch for other works by this author on:Nicholas P. FarrellNicholas P. FarrellDepartment of ChemistryVirginia Commonwealth University, Richmond, VA 23284-2006AustraliaInstitute of GlycomicsGriffith University, Gold Coast Campus, Qld. 4222AustraliaSearch for other works by this author on:
-
Chapter 9: Polyamine-Based Agents for Gene and siRNA Transferp205-237ByIan S. Blagbrough;Ian S. BlagbroughDepartment of Pharmacy and PharmacologyUniversity of Bath, Bath BA2 7AYUKSearch for other works by this author on:Abdelkader A. Metwally;Abdelkader A. MetwallyDepartment of Pharmacy and PharmacologyUniversity of Bath, Bath BA2 7AYUKSearch for other works by this author on:Osama A. A. AhmedOsama A. A. AhmedDepartment of Pharmacy and PharmacologyUniversity of Bath, Bath BA2 7AYUKSearch for other works by this author on:
-
Chapter 10: The Design and Development of Polyamine-Based Analogs with Epigenetic Targetsp238-256ByYi Huang;Yi HuangDepartment of Pharmacology and Chemical BiologyUniversity of Pittsburgh Cancer Institute, 5117 Centre Avenue, University of Pittsburgh, Pittsburgh, PA 15213USASearch for other works by this author on:Laurence J. Marton;Laurence J. MartonDepartment of Laboratory MedicineUniversity of California at San FranciscoSan Francisco, CA 94143, USASearch for other works by this author on:Patrick M. WosterPatrick M. WosterDepartment of Pharmaceutical SciencesWayne State University, Detroit, MI 48202USASearch for other works by this author on:
-
Chapter 11: Clinical Applications of Polyamine-Based Therapeuticsp257-276ByAndré S. Bachmann;André S. BachmannDepartment of Pharmaceutical SciencesCollege of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720USACancer Research Center of HawaiiUniversity of Hawaii at Manoa, Honolulu, HI 96813USASearch for other works by this author on:Victor A. LevinVictor A. LevinDepartment of Neuro-OncologyDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030USADepartment of Neurosurgery and NeurosciencesKaiser Permanente, Redwood City, CA 94063USASearch for other works by this author on:
Spotlight
Advertisement
Advertisement
