Published:11 May 2017
A. B. Frost, M. D. Greenhalgh, and A. D. Smith, in Contemporary Catalysis: Science, Technology, and Applications, ed. P. C. J. Kamer, D. Vogt, and J. Thybaut, The Royal Society of Chemistry, 2017, pp. 416-441.
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This chapter provides a guide to the most popular and reliable synthetic methods used to prepare selected organocatalysts. Some very simple guiding features are suggested that may allow the reader to assess the utility of these synthetic methods based on reliability, modularity and scalability. The main emphasis of this chapter is to give an overview of the synthetic methods available for the preparation of those catalysts most commonly used in enantioselective organocatalysis that are categorised according to the Brønsted acid, Brønsted base, Lewis acid or Lewis base characteristics of the catalyst.