Hormone-Disruptive Chemical Contaminants in Food
Today, we are surrounded by a multitude of different chemicals that are essential components of our everyday life. As a consequence, there are various hazardous substances like dioxins, phthalates and flame-retardants circulating in the environment. These have an impact on ecosystems, wildlife and possibly human health. In recent years, the phenomenon called endocrine disruption has raised considerable concern. This book discusses the scientific basis of this issue using epidemiological and experimental in vitro and in vivo data about chemicals targeting the hormonal systems. It also provides an up-to-date review of international initiatives (including high-throughput screening, use of model organisms and in silico applications) aiming to screen, detect and functionally test these chemicals. The authors are highly experienced academics and acknowledged experts with both multidisciplinary and international expertise. The book provides an up-to-date, in-depth review of the current field of food safety research describing many of the "hot topics" currently debated. Recent media attention concerning, for example, dioxins in meat and bisphenol A in baby bottles has created a growing interest in food safety-related issues from both consumers and authorities. In addition, European legislation REACH, which requires industry to extensively test chemicals, has led to new initiatives within this area. This book presents a comprehensive overview of the recent international initiatives formed to meet the challenges of environmental pollutants in our food.
Hormone-Disruptive Chemical Contaminants in Food, The Royal Society of Chemistry, 2011.
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Table of contents
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Introductionp1-13ByLinda Vikström Bergander;Linda Vikström BerganderDepartment of Biosciences and NutritionKarolinska Institute, SE-141 83 HuddingeSwedenSearch for other works by this author on:Ingemar PongratzIngemar PongratzDepartment of Biosciences and NutritionKarolinska Institute, SE-141 83 HuddingeSwedenSearch for other works by this author on:
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Chapter 2: Persistent Organic Pollutant Levels in Commercial Baby Foods and Estimation of Infants Dietary Exposurep14-25ByKarl-Werner Schramm;Karl-Werner SchrammHelmholtz Zentrum MünchenGerman Research Center for Environmental Health, Institute of Ecological Chemistry, Ingolstädter Landstrasse 1, 85764 NeuherbergGermanyTechnical University of MunichCenter of Life and Food Sciences Weihenstephan, Research Departments Biosciences, Weihenstephaner Steig 23, 85350 FreisingGermanySearch for other works by this author on:Marchela PandelovaMarchela PandelovaHelmholtz Zentrum MünchenGerman Research Center for Environmental Health, Institute of Ecological Chemistry, Ingolstädter Landstrasse 1, 85764 NeuherbergGermanySearch for other works by this author on:
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Chapter 3: Chemicals Targeting the Reproductive Axisp26-43ByK. Svechnikov;K. SvechnikovDepartment of Women's and Children's HealthPediatric Endocrinology Unit, Karolinska Institute & University Hospital, Q2:08, SE-17176 StockholmSwedenSearch for other works by this author on:O. SöderO. SöderDepartment of Women's and Children's HealthPediatric Endocrinology Unit, Karolinska Institute & University Hospital, Q2:08, SE-17176 StockholmSwedenSearch for other works by this author on:
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Chapter 4: Marked For Life: How Environmental Factors Affect the Epigenomep44-69ByPauliina Damdimopoulou;Pauliina DamdimopoulouDepartment of Biosciences and NutritionKarolinska Institute, Hälsovägen 7, 14152 HuddingeSwedenSearch for other works by this author on:Stefan Weis;Stefan WeisDepartment of BiomedicineInstitute of Biochemistry and Genetics, University of Basel, Mattenstrasse 28, 4058 BaselSwitzerlandSearch for other works by this author on:Ivan Nalvarte;Ivan NalvarteFriedrich Miescher InstituteMaulbeerstrasse 66, 4058 BaselSwitzerlandSearch for other works by this author on:Joëlle RüeggJoëlle RüeggDepartment of BiomedicineInstitute of Biochemistry and Genetics, University of Basel, Mattenstrasse 28, 4058 BaselSwitzerlandSearch for other works by this author on:
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Chapter 5: Phytoestrogens: Naturally Occurring, Hormonally Active Compounds in Our Dietp70-92ByKrista A. Power;Krista A. PowerGuelph Food Research CentreAgriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario, Canada, N1G-5C9Search for other works by this author on:Oliver Zierau;Oliver ZierauMolecular Cell Physiology and EndocrinologyInstitute of Zoology, Technical University DresdenGermanySearch for other works by this author on:Shannon O’DwyerShannon O’DwyerGuelph Food Research CentreAgriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario, Canada, N1G-5C9Department of Human Health and Nutritional SciencesUniversity of Guelph, Guelph, OntarioCanadaSearch for other works by this author on:
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Chapter 6: Role of Metabolism in the Bioactivation/Detoxification of Food Contaminantsp93-114ByJean-Pierre Cravedi;Jean-Pierre CravediUMR 1331 TOXALIMINRA, 180 chemin de Tournefeuille, BP 93173, F-31027 Toulouse Cédex 3FranceSearch for other works by this author on:Daniel ZalkoDaniel ZalkoUMR 1331 TOXALIMINRA, 180 chemin de Tournefeuille, BP 93173, F-31027 Toulouse Cédex 3FranceSearch for other works by this author on:
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Chapter 7: Aryl Hydrocarbon Receptor Targeted by Xenobiotic Compounds and Dietary Phytochemicalsp115-135ByJason MatthewsJason MatthewsDepartment of Pharmacology & ToxicologyUniversity of Toronto, Toronto, Ontario, M5S 1A8CanadaSearch for other works by this author on:
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Chapter 8: Small Model Organisms as Tools in Food Safety Researchp136-153ByMarie Tohme;Marie TohmeInstitut de Génomique Fonctionnelle de LyonEcole Normale Supérieure de Lyon, Université Lyon 1, CNRS, Université de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07FranceSearch for other works by this author on:Jean-Baptiste Fini;Jean-Baptiste FiniCNRS UMR 7221Département Régulations, Développement et Diversité Moléculaire, Muséum National d’Histoire Naturelle, 7 rue Cuvier, 7231 Paris Cedex 5FranceSearch for other works by this author on:Vincent Laudet;Vincent LaudetInstitut de Génomique Fonctionnelle de LyonEcole Normale Supérieure de Lyon, Université Lyon 1, CNRS, Université de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07FranceSearch for other works by this author on:Barbara DemeneixBarbara DemeneixCNRS UMR 7221Département Régulations, Développement et Diversité Moléculaire, Muséum National d’Histoire Naturelle, 7 rue Cuvier, 7231 Paris Cedex 5FranceSearch for other works by this author on:
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Chapter 9: Application of Reporter Animals as Novel Tools in Food Safety Researchp154-169ByBalaji Ramachandran;Balaji RamachandranCenter of Excellence on Neurodegenerative Diseases and Department of Pharmacological SciencesUniversity of Milan, Via Balzaretti 9, I-20123 MilanItalySearch for other works by this author on:Adriana MaggiAdriana MaggiCenter of Excellence on Neurodegenerative Diseases and Department of Pharmacological SciencesUniversity of Milan, Via Balzaretti 9, I-20123 MilanItalySearch for other works by this author on:
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Chapter 10: In Silico Approaches to Screening Dietary Endocrine Disruptorsp170-183ByRodolfo Gonella Diaza;Rodolfo Gonella DiazaInstitute for Pharmaceutical Researches “Mario Negri”Via La Masa 19, 20156 MilanoItalySearch for other works by this author on:Alessandra Roncaglioni;Alessandra RoncaglioniInstitute for Pharmaceutical Researches “Mario Negri”Via La Masa 19, 20156 MilanoItalySearch for other works by this author on:Emilio BenfenatiEmilio BenfenatiInstitute for Pharmaceutical Researches “Mario Negri”Via La Masa 19, 20156 MilanoItalySearch for other works by this author on:
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Chapter 11: Application of Percellome Toxicogenomics to Food Safetyp184-198ByJ. Kanno;J. KannoNational Institute of Health SciencesTokyo 158-8501JapanSearch for other works by this author on:K. Aisaki;K. AisakiNational Institute of Health SciencesTokyo 158-8501JapanSearch for other works by this author on:K. Igarashi;K. IgarashiNational Institute of Health SciencesTokyo 158-8501JapanSearch for other works by this author on:N. Nakatsu;N. NakatsuNational Institute of Health SciencesTokyo 158-8501JapanNational Institute of Biomedical InnovationOsaka 567-0085JapanSearch for other works by this author on:Y. Kodama;Y. KodamaNational Institute of Health SciencesTokyo 158-8501JapanSearch for other works by this author on:K. Sekita;K. SekitaNational Institute of Health SciencesTokyo 158-8501JapanSearch for other works by this author on:A. Takagi;A. TakagiNational Institute of Health SciencesTokyo 158-8501JapanSearch for other works by this author on:S. KitajimaS. KitajimaNational Institute of Health SciencesTokyo 158-8501JapanSearch for other works by this author on:
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Chapter 12: Occurrence of Endocrine Disrupters in Food Chainsp199-215ByAlberto Mantovani;Alberto MantovaniFood and Veterinary Toxicology UnitDepartment of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 RomeItalySearch for other works by this author on:Ilaria ProiettiIlaria ProiettiFood and Veterinary Toxicology UnitDepartment of Veterinary Public Health and Food Safety, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 RomeItalyAgrisystemCatholic University of “Sacro Cuore”, Via Emilia Parmense 84, 29122 PiacenzaItalySearch for other works by this author on:
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