Neglected Diseases and Drug Discovery
There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas that remain highly neglected. All the major diseases such as malaria, trypanosomatids and TB are covered, with a review of each disease and established compounds, new mechanistic classes and new horizons. Each chapter highlights the key science that has led to breakthroughs, with detailed assessment of the key medicinal chemistry involved, and critical appraisal of new emerging approaches. Later chapters highlight under publicized disease areas where the medical needs are neglected and research is very limited, to raise awareness. The editors, acknowledged experts in the field, have a wealth of experience in successful drug discovery practice and tropical diseases.
Neglected Diseases and Drug Discovery, The Royal Society of Chemistry, 2011.
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Table of contents
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Malaria: New Medicines for its Control and Eradicationp1-32ByTimothy N. C. Wells;Timothy N. C. WellsMedicines for Malaria Venture20 Rte de Pré-Bois, 1215 GenevaSwitzerlandSearch for other works by this author on:Winston E. GutteridgeWinston E. GutteridgeMedicines for Malaria Venture20 Rte de Pré-Bois, 1215 GenevaSwitzerlandSearch for other works by this author on:
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Chapter 2: Semisynthetic Artemisinin and Synthetic Peroxide Antimalarialsp33-64ByLeann Tilley;Leann TilleyDepartment of Biochemistry and Centre of Excellence for Coherent X-rayScience, La Trobe UniversityMelbourne, Victoria 3086Australia;Search for other works by this author on:Susan A. Charman;Susan A. CharmanCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical SciencesMonash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052AustraliaSearch for other works by this author on:Jonathan L. VennerstromJonathan L. VennerstromCollege of PharmacyUniversity of Nebraska Medical Center, 986025 Nebraska Medical Center, OmahaNEUSASearch for other works by this author on:
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Chapter 3: Antimalarial Agents Targeting Nucleotide Synthesis and Electron Transport: Insight from Structural Biologyp65-87ByMargaret A. PhillipsMargaret A. PhillipsDepartment of PharmacologyUniversity of Texas Southwestern Medical CenterDallasTexas75390-9041USSearch for other works by this author on:
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Chapter 4: Human Targets Repositioning and Cell-based Approaches for Antimalarial Discoveryp88-111ByArnab K. Chatterjee;Arnab K. ChatterjeeGenomics Institute of the Novartis Research Foundation10675 John J. Hopkins Dr., Room C226, San Diego, CA 92121, USSearch for other works by this author on:Elizabeth A. WinzelerElizabeth A. WinzelerGenomics Institute of the Novartis Research Foundation10675 John J. Hopkins Dr., Room C226, San Diego, CA 92121, USSearch for other works by this author on:
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Chapter 5: The Medicinal Chemistry of Eradication: Hitting the Lifecycle where it Hurts.p112-133ByJeremy Nicholas Burrows;Jeremy Nicholas BurrowsMedicines for Malaria VentureRoute de Pré-Bois 20Geneva 1215SwitzerlandSearch for other works by this author on:Robert Edward SindenRobert Edward SindenDepartment of Life SciencesImperial College LondonSouth KensingtonLondon SW7 2AZUKSearch for other works by this author on:
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Chapter 6: Drugs for Kinetoplastid Diseases – Current Situation and Challengesp134-158BySimon L. CroftSimon L. CroftFaculty of Infectious and Tropical DiseasesLondon School of Hygiene & Tropical Medicine, London WC1E 7HT, UKSearch for other works by this author on:
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Chapter 7: Drug Discovery for Kinetoplastid Diseasesp159-202ByRobert T. JacobsRobert T. JacobsSCYNEXIS, Inc.P. O. Box 12878Research Triangle ParkNC 27709-2878USSearch for other works by this author on:
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Chapter 8: The Challenges of Flavivirus Drug Discoveryp203-227ByPei-Yong Shi;Pei-Yong ShiNovartis Institute for Tropical Diseases10 Biopolis Road, #05-01 ChromosSingapore 138670Search for other works by this author on:Qing-Yin Wang;Qing-Yin WangNovartis Institute for Tropical Diseases10 Biopolis Road, #05-01 ChromosSingapore 138670Search for other works by this author on:Thomas H. KellerThomas H. KellerExperimental Therapeutics Center31 Biopolis Way, #03-01 NanosSingapore 138669Search for other works by this author on:
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Chapter 9: Current Approaches to Tuberculosis Drug Discovery and Developmentp228-261ByMark J. Mitton-Fry;Mark J. Mitton-FryPfizer, Antibacterials Medicinal ChemistryPharmaTherapeutics, Eastern Point Road, Groton, CT 06340, MS 8220-2464USSearch for other works by this author on:Debra HannaDebra HannaCritical Path Institute1730 E River Road, Tucson, Arizona 85718USASearch for other works by this author on:
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Chapter 10: Diarrhoeal Diseasesp262-289ByDavid Brown,, PhD, CChem, FRSCDavid Brown,, PhD, CChem, FRSCAlchemy Biomedical ConsultingCambridge, UKSearch for other works by this author on:
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Chapter 11: Anthelmintic Discovery for Human Infectionsp290-321ByTimothy G. Geary;Timothy G. GearyMcGill UniversityInstitute of Parasitology, 21,111 Lakeshore Road, Ste-Anne de Bellevue, H9X 3V9QuebecCanadaSearch for other works by this author on:Noelle GauvryNoelle GauvryNovartis Animal Health Inc.Chemistry and Bioactives, Schwarzwaldallee 215, CH-4002BaselSwitzerlandSearch for other works by this author on:
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Chapter 12: Managing the HIV Epidemic in the Developing World – Progress and Challengesp322-365ByElna van der Ryst;Elna van der RystPfizer Global Research and DevelopmentRamsgate Road, Sandwich, CT13 9NJUnited KingdomSearch for other works by this author on:Michael J Palmer;Michael J PalmerPfizer Global Research and DevelopmentRamsgate Road, Sandwich, CT13 9NJUnited KingdomSearch for other works by this author on:Cloete van VuurenCloete van VuurenFaculty of Health SciencesUniversity of the Free StateBloemfontein9301South AfricaSearch for other works by this author on:
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Chapter 13: Drug Discovery for Lower Respiratory Tract Infectionsp366-411ByJ Carl Craft, MDJ Carl Craft, MD318 Camelot LaneLibertyville, Illinois 60048, USASearch for other works by this author on:
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