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Issues in Toxicology
Reducing, Refining and Replacing the Use of Animals in Toxicity TestingCheck Access
Edited by
Dave Allen;
Dave Allen
Integrated Laboratory Systems Inc., USA
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Mike D Waters
Mike D Waters
Integrated Laboratory Systems (ILS) Inc., USA
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Hardback ISBN:
978-1-84973-652-7
PDF ISBN:
978-1-84973-792-0
Series:
Issues in Toxicology
No. of Pages:
362
Publication date:
31 Oct 2013
Book Chapter
CHAPTER 9: Integrated Approaches to Safety Testing: General Principles and Skin Sensitization as Test Case Check Access
By
Andreas Natsch
Andreas Natsch
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Published:31 Oct 2013
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Series: Issues in Toxicology
Page range:
265 - 288
Citation
A. Natsch, in Reducing, Refining and Replacing the Use of Animals in Toxicity Testing, ed. D. Allen and M. D. Waters, The Royal Society of Chemistry, 2013, pp. 265-288.
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Integrated testing strategies (ITS) were proposed to predict toxicity endpoints based on data integration from different sources of mainly non-animal test information. Here the principle limitations of in vitro testing which may be overcome by an ITS are described and the theoretical frame of how data from different sources can be integrated is discussed. These principles are then applied to systematically present possibilities for data integration for the skin sensitization endpoint, and to review attempts which have been made in this field.
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