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Issues in Toxicology
Advances in Dermatological Sciences
Edited by
Robert Chilcott;
Robert Chilcott
Health Protection Agency, UK
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Keith R. Brain
Keith R. Brain
University of Cardiff, UK
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Hardback ISBN:
978-1-84973-398-4
PDF ISBN:
978-1-84973-463-9
Series:
Issues in Toxicology
No. of Pages:
474
Published online:
05 Dec 2013
Published in print:
06 Dec 2013
Book Chapter
The Effect of Heat on Diclofenac Permeation Through Human Skin
By
F. Caserta
;
F. Caserta
School of Pharmacy
University of Hertfordshire
UK
MedPharm Ltd.
Surrey
UK
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M. B. Brown
;
M. B. Brown
School of Pharmacy
University of Hertfordshire
UK
MedPharm Ltd.
Surrey
UK
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W. J. McAuley
W. J. McAuley
School of Pharmacy
University of Hertfordshire
UK
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Published:05 Dec 2013
-
Series: Issues in Toxicology
Page range:
157 - 168
Citation
F. Caserta, D. G. Wood, M. B. Brown, and W. J. McAuley, in Advances in Dermatological Sciences, ed. R. Chilcott and K. R. Brain, The Royal Society of Chemistry, 2013, pp. 157-168.
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The application of thermal energy to enhance the percutaneous absorption of drugs offers an encouraging prospect for overcoming the skin barrier. External membranes such as the skin present a considerable barrier to the permeation of drugs, limiting the types of treatment that can be given via this route. These barrier properties are mostly dependent on the stratum corneum (SC), the outermost layer of skin, which in most cases is known to be the rate limiting step for drug diffusion across the skin.
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