Iontophoretic Delivery of Glycomimetics-A New Approach for the Treatment of Inflammatory Skin Diseases
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Published:05 Dec 2013
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Series: Issues in Toxicology
T. Gratieri, B. Wagner, D. Kalaria, B. Ernst, and Y. N. Kalia, in Advances in Dermatological Sciences, ed. R. Chilcott and K. R. Brain, The Royal Society of Chemistry, 2013, pp. 178-188.
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A key event in the inflammatory response is the recruitment of leukocytes from the microcirculation to the inflamed tissue through endothelial-dependent mechanisms that include leukocyte tethering and rolling, activation, firm adhesion and diapedesis to the interstitium. Leukocyte tethering and rolling along the endothelial surface is mediated by a family of carbohydrate-binding proteins (E-, P- and L-selectins). While L-selectin is constitutively expressed on the surface of leukocytes, expression of E- and P-selectin is upregulated on the endothelial surface during inflammation.
