The Effect of Sulfur Mustard Exposure and Freezing on Transdermal Penetration of Tritiated Water Through Ex Vivo Pig Skin
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Published:05 Dec 2013
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Series: Issues in Toxicology
O. J. Payne, S. J. Graham, C. H. Dalton, P. M. Spencer, R. Mansson, J. Jenner, ... E. Braue, in Advances in Dermatological Sciences, ed. R. Chilcott and K. R. Brain, The Royal Society of Chemistry, 2013, pp. 417-427.
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Sulfur mustard (SM) is a well known and potent vesicating agent that has been used in many conflicts during the twentieth century. Cutaneous sulfur mustard injuries are often painfully debilitating, requiring surgical intervention (e.g., tissue debridement) and specialist burn care support. Wounds can take months to heal and place a substantial burden on the medical chain. Topical pharmaceutical formulations as medical countermeasures to cutaneous sulfur mustard injuries carry important advantages, including ease and non-invasiveness of dermal application, and effectiveness in reducing SM associated skin damage.
