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Issues in Toxicology
Advances in Dermatological Sciences
Edited by
Robert Chilcott;
Robert Chilcott
Health Protection Agency, UK
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Keith R. Brain
Keith R. Brain
University of Cardiff, UK
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Hardback ISBN:
978-1-84973-398-4
PDF ISBN:
978-1-84973-463-9
Series:
Issues in Toxicology
No. of Pages:
474
Publication date:
05 Dec 2013
Book Chapter
Modulation of Sulphur Mustard Skin Absorption by Topical Delivery of Fatty Acids and Cholesterol
By
R. P. Chilcott
;
R. P. Chilcott
Biomedical Sciences Department
Defence Science and Technology Laboratory, Porton Down, Salisbury
United Kingdom
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O. J. Hutton
;
O. J. Hutton
Biomedical Sciences Department
Defence Science and Technology Laboratory, Porton Down, Salisbury
United Kingdom
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J. Jenner
J. Jenner
Biomedical Sciences Department
Defence Science and Technology Laboratory, Porton Down, Salisbury
United Kingdom
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Published:05 Dec 2013
-
Series: Issues in Toxicology
Page range:
428 - 434
Citation
R. P. Chilcott, O. J. Hutton, and J. Jenner, in Advances in Dermatological Sciences, ed. R. Chilcott and K. R. Brain, The Royal Society of Chemistry, 2013, pp. 428-434.
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Sulphur mustard (SM) is a chemical warfare agent that causes severe skin lesions. Previous work has shown that 80% of an applied liquid droplet of SM will vaporise from the skin surface before absorption can occur. There are a number of potential methods to increase the vapour loss of SM from the skin surface (thereby decreasing the dose received by the skin). These include use of an appropriate barrier cream or topical application of compounds that limit partitioning of SM into the skin.
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