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RSC Biomolecular Sciences
Structural Virology
Edited by
Mavis Agbandje-McKenna;
Mavis Agbandje-McKenna
University of Florida, USA
Search for other works by this author on:
Robert McKenna
Robert McKenna
University of Florida, USA
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Hardback ISBN:
978-0-85404-171-8
PDF ISBN:
978-1-84973-223-9
No. of Pages:
388
Publication date:
11 Nov 2010
About this book
Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
Structural Virology, The Royal Society of Chemistry, 2010.
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Digital access
$186.00
Print format
Structural Virology
$186.00
Table of contents
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Chapter 1: Production and Purification of Viruses for Structural Studiesp1-21ByBrittney L. Gurda;Brittney L. GurdaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:Mavis Agbandje-McKennaMavis Agbandje-McKennaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:
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Chapter 2: Microscopic Analysis of Viral Cell Binding, Entry and Infection in Live Cellsp22-40ByColin R. ParrishColin R. ParrishBaker Institute for Animal Health, College of Veterinary Medicine, Cornell UniversityIthacaNY 14850USASearch for other works by this author on:
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Chapter 3: Probing Viral Capsids in Solutionp41-61ByBrian Bothner;Brian BothnerDepartment of Chemistry and Biochemistry, Montana State UniversityBozemanMT 59717USASearch for other works by this author on:Jonathan K. HilmerJonathan K. HilmerDepartment of Chemistry and Biochemistry, Montana State UniversityBozemanMT 59717USASearch for other works by this author on:
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Chapter 4: Three-dimensional Structures of Pleiomorphic Viruses from Cryo-Electron Tomographyp62-80ByAlasdair C. Steven;Alasdair C. StevenLaboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:Giovanni Cardone;Giovanni CardoneLaboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:Carmen Butan;Carmen ButanLaboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:Dennis C. Winkler;Dennis C. WinklerLaboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:J. Bernard HeymannJ. Bernard HeymannLaboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:
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Chapter 5: Structure Determination of Icosahedral Viruses Imaged by Cryo-electron Microscopyp81-99ByRobert S. Sinkovits;Robert S. SinkovitsDepartment of Chemistry and Biochemistry, University of California, San DiegoLa JollaCA 92093USASan Diego Supercomputer Center, University of California, San DiegoLa JollaCA 92093USASearch for other works by this author on:Timothy S. BakerTimothy S. BakerDepartment of Chemistry and Biochemistry, University of California, San DiegoLa JollaCA 92093USADivision of Biological Sciences, University of California, San DiegoLa JollaCA 92093USASearch for other works by this author on:
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Chapter 6: X-ray Crystallography of Virus Capsidsp100-120ByLakshmanan Govindasamy;Lakshmanan GovindasamyDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:Mavis Agbandje-McKenna;Mavis Agbandje-McKennaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:Robert McKennaRobert McKennaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:
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Chapter 7: Structural Studies of Viral Proteins – X-ray Crystallographyp121-134ByJohn Domsic;John DomsicDepartment of Biochemistry and Molecular BiologyCenter for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:Robert McKennaRobert McKennaDepartment of Biochemistry and Molecular BiologyCenter for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:
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Chapter 8: Solution NMR Spectroscopy in Characterizing Structure, Dynamics and Intermolecular Interactions of Retroviral Structural Proteinsp135-159ByKang Chen;Kang ChenLaboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:Nico TjandraNico TjandraLaboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:
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Chapter 9: Evolution of Viral Capsid Structures – the Three Domains of Lifep161-179ByReza Khayat;Reza KhayatDepartment of Molecular Biology, The Scripps Research InstituteLa JollaCA 92037USASearch for other works by this author on:John E. JohnsonJohn E. JohnsonDepartment of Molecular Biology, The Scripps Research InstituteLa JollaCA 92037USASearch for other works by this author on:
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Chapter 10: Mechanisms of Icosahedral Virus Assemblyp180-202ByAdam Zlotnick;Adam ZlotnickDepartment of Biology, Indiana UniversityBloomingtonIN 47405USASearch for other works by this author on:Bentley A. FaneBentley A. FaneDivision of Plant Pathology and Microbiology, Department of Plant Sciences and The BIO5 Institute, University of ArizonaTucsonAZ 85721USASearch for other works by this author on:
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Chapter 11: Mechanisms of Genome Packagingp203-219ByMark Oram;Mark OramDepartment of Biochemistry and Molecular Biology, University of Maryland School of MedicineBaltimoreMD 21201USASearch for other works by this author on:Lindsay W. BlackLindsay W. BlackDepartment of Biochemistry and Molecular Biology, University of Maryland School of MedicineBaltimoreMD 21201USASearch for other works by this author on:
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Chapter 12: Attachment and Entry: Receptor Recognition in Viral Pathogenesisp220-242ByDamian C. Ekiert;Damian C. EkiertDepartment of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research InstituteLa JollaCA 92037USASearch for other works by this author on:Ian A. WilsonIan A. WilsonDepartment of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research InstituteLa JollaCA 92037USASearch for other works by this author on:
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Chapter 13: Attachment and Entry: Viral Cell Fusionp243-260ByRachel M. Schowalter;Rachel M. SchowalterLaboratory of Cellular OncologyCenter for Cancer Research, National Cancer InstituteNational Institutes of HealthBethesdaMD 20892USASearch for other works by this author on:Everett C. Smith;Everett C. SmithDepartment of Molecular and Cellular BiochemistryUniversity of Kentucky College of MedicineLexingtonKY 40536USASearch for other works by this author on:Rebecca Ellis DutchRebecca Ellis DutchDepartment of Molecular and Cellular BiochemistryUniversity of Kentucky College of MedicineLexingtonKY 40536USASearch for other works by this author on:
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Chapter 14: Structural Studies on Antibody–Virus Complexesp261-289ByThomas J. SmithThomas J. SmithDonald Danforth Plant Science Center, 975 North Warson RoadSt. LouisMO 63132USASearch for other works by this author on:
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Chapter 15: Development of Anti-HIV Drugsp291-318ByRoxana M. Coman;Roxana M. ComanDepartment of Biochemistry and Molecular BiologyCenter for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:Robert McKennaRobert McKennaDepartment of Biochemistry and Molecular BiologyCenter for Structural Biology, The McKnight Brain Institute, University of FloridaGainesvilleFL 32610USASearch for other works by this author on:
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Chapter 16: Design of Capsid-binding Antiviral Agents Against Human Rhinovirusesp319-337ByChuan Xiao;Chuan XiaoDepartment of Biological SciencesPurdue University, 915 W. State StreetWest LafayetteIN 47907USASearch for other works by this author on:Mark A. McKinlay;Mark A. McKinlayTetraLogic Pharmaceuticals343 Phoenixville PikeMalvernPA 19355USASearch for other works by this author on:Michael G. RossmannMichael G. RossmannDepartment of Biological SciencesPurdue University, 915 W. State StreetWest LafayetteIN 47907USASearch for other works by this author on:
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Chapter 17: Viral Vectors for Gene Deliveryp338-357ByDavid J. Dismuke;David J. DismukeUNC Gene Therapy CenterUniversity of North CarolinaChapel HillNC 27599USASearch for other works by this author on:Steven J. Gray;Steven J. GrayUNC Gene Therapy CenterUniversity of North CarolinaChapel HillNC 27599USASearch for other works by this author on:Matthew L. Hirsch;Matthew L. HirschUNC Gene Therapy CenterUniversity of North CarolinaChapel HillNC 27599USASearch for other works by this author on:Richard Samulski;Richard SamulskiUNC Gene Therapy CenterUniversity of North CarolinaChapel HillNC 27599USASearch for other works by this author on:Nicholas MuzyczkaNicholas MuzyczkaUF Powell Gene Therapy CenterUniversity of Florida College of MedicineGainesvilleFL 32610USASearch for other works by this author on:
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