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Issues in Toxicology
Manganese in Health and Disease
Edited by
Michael Aschner
Michael Aschner
Vanderbilt University, USA
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Hardback ISBN:
978-1-84973-943-6
PDF ISBN:
978-1-78262-238-3
EPUB ISBN:
978-1-78262-350-2
Special Collection:
2014 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Issues in Toxicology
No. of Pages:
632
Published online:
27 Nov 2014
Published in print:
05 Dec 2014
Book Chapter
Chapter 24: DNA Damage Induced by Manganese
By
Julia Bornhorst
;
Julia Bornhorst
Institute of Nutritional Sciences, University of Potsdam
Arthur-Scheunert-Allee 114-116
14558
Nuthetal
Germany
[email protected][email protected]
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Tanja Schwerdtle
Tanja Schwerdtle
Institute of Nutritional Sciences, University of Potsdam
Arthur-Scheunert-Allee 114-116
14558
Nuthetal
Germany
[email protected][email protected]
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Published:27 Nov 2014
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Special Collection: 2014 ebook collection , 2011-2015 industrial and pharmaceutical chemistry subject collectionSeries: Issues in Toxicology
Page range:
604 - 620
Citation
J. Bornhorst and T. Schwerdtle, in Manganese in Health and Disease, ed. L. Costa and M. Aschner, The Royal Society of Chemistry, 2014, ch. 24, pp. 604-620.
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This chapter summarizes the current studies on the genotoxic potential of manganese (Mn) and is thereby points out that the knowledge gained up to now is quite equivocal. Besides reviewing the current literature on Mn-induced DNA damage on a chromosomal as well as a DNA level, possible underlying mechanisms, including disturbances of DNA replication/DNA polymerases as well as DNA damage response pathways, are discussed. Finally, this chapter gives a brief overview of the possible consequences of DNA damage induced by manganese.
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