Skip Nav Destination
Drug Discovery
New Horizons in Predictive Toxicology: Current Status and Application
Edited by
Alan G E Wilson
Alan G E Wilson
Lexicon Pharmaceuticals, USA
Search for other works by this author on:
Hardback ISBN:
978-1-84973-051-8
PDF ISBN:
978-1-84973-304-5
Special Collection:
2011 ebook collection
,
2011 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery Series
No. of Pages:
732
Published online:
15 Nov 2011
Published in print:
25 Nov 2011
About this book
Modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of great importance. Such approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including the in silico, in vitro and in vivo approaches being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen our ability to predict the risks posed by industrial and pharmaceutical chemicals in humans. Extensive information on the use of current animal models used for various toxicities and target-mediated toxicities is included. Also discussed are the recently introduced regulatory initiatives.
New Horizons in Predictive Toxicology: Current Status and Application, The Royal Society of Chemistry, 2011.
Download citation file:
Digital access
$251.00
Print format
New Horizons in Predictive Toxicology
$251.00
Table of contents
-
Introduction and Overviewp1-8ByAlan G. E. WilsonAlan G. E. WilsonLexicon Pharmaceuticals Inc.Drug Metabolism, Pharmacokinetics, Toxicology and Pathology, 8800 Technology Forest Place, The Woodlands, Texas 77381-1160USASearch for other works by this author on:
-
Chapter 2: In Silico Tools for Toxicity Predictionp9-25ByMark T. D. CroninMark T. D. CroninSchool of Pharmacy and ChemistryLiverpool John Moores University, Byrom Street, Liverpool, L3 3AFUKSearch for other works by this author on:
-
Chapter 3: Development of an Evaluation Support System for Estimating Repeated-Dose Toxicity of Chemicals Based on Chemical Structurep26-37ByMakoto Hayashi;Makoto HayashiBiosafety Research CenterFoods, Drugs and Pesticides, 582-2, Shioshinden, Iwata, Shizuoka 437-1213JapanNational Institute of Technology and EvaluationChemical Management Center, 2-49-10, Nishihara, Shibuya-ku, Tokyo 151-0066JapanSearch for other works by this author on:Yuki SakurataniYuki SakurataniNational Institute of Technology and EvaluationChemical Management Center, 2-49-10, Nishihara, Shibuya-ku, Tokyo 151-0066JapanSearch for other works by this author on:
-
Chapter 4: Towards a Common Regulatory Framework for Computational Toxicology: Current Status and Future Perspectivesp38-69ByAndrew P. Worth;Andrew P. WorthEuropean CommissionJoint Research Centre, Institute for Health and Consumer Protection, Via E. Fermi, 21027 Ispra, VAItalySearch for other works by this author on:Aleksandra Mostrag-SzlichtyngAleksandra Mostrag-SzlichtyngEuropean CommissionJoint Research Centre, Institute for Health and Consumer Protection, Via E. Fermi, 21027 Ispra, VAItalySearch for other works by this author on:
-
Chapter 5: Information, Informatics and Modeling in Predictive Toxicologyp70-100ByScott Boyer;Scott BoyerAstraZeneca R&DComputational Toxicology, Global Safety Assessment, MölndalSwedenSearch for other works by this author on:Daniel Muthas;Daniel MuthasAstraZeneca R&DComputational Toxicology, Global Safety Assessment, MölndalSwedenSearch for other works by this author on:Nigel GreeneNigel GreenePfizer Global Research and DevelopmentGroton, CT 06340USASearch for other works by this author on:
-
Chapter 6: Cellular Stress and In Vitro Predictive Toxicologyp101-119ByXuemei Liu;Xuemei LiuAlcon Research LtdPreclinical Safety, 6201 South Freeway, Fort Worth, TX 76134USASearch for other works by this author on:Jeffrey A. Kramer;Jeffrey A. KramerAlcon Research LtdPreclinical Safety, 6201 South Freeway, Fort Worth, TX 76134USASearch for other works by this author on:Alan G. E. WilsonAlan G. E. WilsonLexicon Pharmaceuticals Inc.Drug Metabolism, Pharmacokinetics, Toxicology and Pathology, 8800 Technology Forest Place, The Woodlands, TX 77381-1160USASearch for other works by this author on:
-
Chapter 7: In Vitro Genotoxicityp120-146ByJohn J. Nicolette;John J. NicoletteAbbott Laboratories, Abbott Park, IL 60064-6112USASearch for other works by this author on:Sundar Venkatachalam;Sundar VenkatachalamBiochemistry & Cellular Molecular Biology DepartmentUniversity of Tennessee, KnoxvilleTN 37996USASearch for other works by this author on:Brinda Mahadevan;Brinda MahadevanAbbott Laboratories, Abbott Park, IL 60064-6112USASearch for other works by this author on:Patricia A. EscobarPatricia A. EscobarBoehringer Ingelheim PharmaceuticalsRidgefieldCT 06877-0368USASearch for other works by this author on:
-
Chapter 8: Cardiac Toxicity Prediction: To Simplify, or to Integrate, that is the Questionp147-156ByVivek J. Kadambi;Vivek J. KadambiMillennium: The Takeda Oncology CompanyDrug Safety Evaluation, 35 Landsdowne Street, Cambridge, MA 02139USASearch for other works by this author on:Colleen Synan;Colleen SynanMillennium: The Takeda Oncology CompanyDrug Safety Evaluation, 35 Landsdowne Street, Cambridge, MA 02139USASearch for other works by this author on:Katherine BrewerKatherine BrewerMillennium: The Takeda Oncology CompanyDrug Safety Evaluation, 35 Landsdowne Street, Cambridge, MA 02139USASearch for other works by this author on:
-
Chapter 9: In Vitro Approaches for Determining Liver-Specific Toxicity of New Drug Candidatesp157-220ByJames M. McKim JrJames M. McKim JrCeeTox Inc.4717 Campus Drive, Kalamazoo, MI49008USASearch for other works by this author on:
-
Chapter 10: Human-based In Vitro Experimental Systems for the Assessment of Human-Specific Adverse Drug Effects: Scientific Concepts, Current Applications and Promising Approachesp221-248ByAlbert P. LiAlbert P. LiIn vitro ADMET Laboratories LLC and Advanced Pharmaceutical Sciences Inc.9221 Rumsey Road, Suite 8, Columbia, MD 21045USASearch for other works by this author on:
-
Chapter 11: Pathways of Organ Injury to Define Human Response in Organotypic Culturesp249-282ByAlison E. M. VickersAlison E. M. VickersAllergan Inc.Investigative Sciences, 2525 Dupont Drive, Irvine, CA 92612USASearch for other works by this author on:
-
Chapter 12: Predicting Drug-Induced Mitochondrial Dysfunctionp283-306BySashi Nadanaciva;Sashi NadanacivaPfizer Global R&DCompound Safety Prediction, Eastern Point Road, Groton CT, 06340USASearch for other works by this author on:Yvonne WillYvonne WillPfizer Global R&DCompound Safety Prediction, Eastern Point Road, Groton CT, 06340USASearch for other works by this author on:
-
Chapter 13: Non-Clinical Models for the Evaluation of Mechanisms of Toxicityp307-329ByJeffrey A. KramerJeffrey A. KramerAlcon Research Ltd.Department of Preclinical Safety, 6201 South Freeway, Fort Worth, TX 76134USASearch for other works by this author on:
-
Chapter 14: In Vivo Approaches to Predictive Toxicology Using Zebrafishp330-355ByMichael T. Simonich;Michael T. SimonichOregon State UniversityDepartment of Environmental & Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center, Corvallis, OR 97333USASearch for other works by this author on:Jill A. Franzosa;Jill A. FranzosaOregon State UniversityDepartment of Environmental & Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center, Corvallis, OR 97333USASearch for other works by this author on:Robert L. Tanguay*Robert L. Tanguay*Oregon State UniversityDepartment of Environmental & Molecular Toxicology, the Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center, Corvallis, OR 97333USASearch for other works by this author on:
-
Chapter 15: In Vivo Genetic Toxicology: Application to Cancer Risk Assessmentp356-398ByMichael J. Schlosser;Michael J. SchlosserWIL Research Company8025 Lamon Avenue, Skokie, IllinoisUSASearch for other works by this author on:Christopher S. FarabaughChristopher S. FarabaughWIL Research Company8025 Lamon Avenue, Skokie, IllinoisUSASearch for other works by this author on:
-
Chapter 16: Predicting Hepatotoxicity In Vivop399-435ByTimothy MaziaszTimothy MaziaszAllergan Inc.PO Box 19534, Irvine, CA92612USASearch for other works by this author on:
-
Chapter 17: Immunotoxicity Testingp436-463ByThomas T. Kawabata;Thomas T. KawabataPfizer Inc.Drug Safety Research and Development, Groton, CT 06340USASearch for other works by this author on:Sandra Casinghino;Sandra CasinghinoPfizer Inc.Drug Safety Research and Development, Groton, CT 06340USASearch for other works by this author on:Mark Collinge;Mark CollingePfizer Inc.Drug Safety Research and Development, Groton, CT 06340USASearch for other works by this author on:Cris Kamperschroer;Cris KamperschroerPfizer Inc.Drug Safety Research and Development, Groton, CT 06340USASearch for other works by this author on:Jessica WhritenourJessica WhritenourPfizer Inc.Drug Safety Research and Development, Groton, CT 06340USASearch for other works by this author on:
-
Chapter 18: In Vitro Developmental Models and Their Applications in Teratology Researchp464-485ByKaren Augustine-Rauch;Karen Augustine-RauchBristol–Myers SquibbDiscovery Toxicology Group, 311 Pennington-Hopewell Road, Pennington, NJ 08534USASearch for other works by this author on:Julieta M. Panzica-Kelly;Julieta M. Panzica-KellyBristol–Myers SquibbDiscovery Toxicology Group, 311 Pennington-Hopewell Road, Pennington, NJ 08534USASearch for other works by this author on:Cindy X. ZhangCindy X. ZhangBristol–Myers SquibbDiscovery Toxicology Group, 311 Pennington-Hopewell Road, Pennington, NJ 08534USASearch for other works by this author on:
-
Chapter 19: Role and Status of Bridging Biomarkers in Predictive Toxicologyp486-498ByWilliam B. MattesWilliam B. MattesPharmPoint Consulting17014 Hersperger Lane, Poolesville, MD 20837USASearch for other works by this author on:
-
Chapter 20: Renal Toxicityp499-541ByM. Khan;M. KhanPfizerWorldwide R&D, Drug Safety Research and Development, Groton, CT 06340USASearch for other works by this author on:Gordon C. Hard;Gordon C. HardPrivate Consultant, 203 Paku DriveTairua 3508New ZealandSearch for other works by this author on:Zaher A. RadiZaher A. RadiPfizerWorldwide R&D, Drug Safety Research and Development, Cambridge, MA 02140USASearch for other works by this author on:
-
Chapter 21: Metabolism-Based Toxicology Predictionp542-562ByF. Peter GuengerichF. Peter GuengerichVanderbilt University School of MedicineDepartment of Biochemistry and Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, Tennessee 37232-0146USASearch for other works by this author on:
-
Chapter 22: Impact of Drug Transporters in the Pharmacological and Adverse Reactions of Drugsp563-598ByHiroyuki Kusuhara;Hiroyuki KusuharaThe University of TokyoLaboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033JapanSearch for other works by this author on:Kazuya Maeda;Kazuya MaedaThe University of TokyoLaboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033JapanSearch for other works by this author on:Yuichi SugiyamaYuichi SugiyamaThe University of TokyoLaboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033JapanSearch for other works by this author on:
-
Chapter 23: Toxicokineticsp599-618ByDennis A. SmithDennis A. SmithPfizer Global Research and DevelopmentRamsgate Road, Sandwich, Kent, CT13 9NJUKSearch for other works by this author on:
-
Chapter 24: The Role of Computational Systems Biology Models in Toxicity Testing in the 21st Century: an Example with Predictive Multi-Scale Models of the Liverp619-641BySudin Bhattacharya;Sudin BhattacharyaThe Hamner Institutes for Health SciencesProgram in Chemical Safety Sciences, Research Triangle Park, NC 27709- 2137USASearch for other works by this author on:Qiang Zhang;Qiang ZhangThe Hamner Institutes for Health SciencesProgram in Chemical Safety Sciences, Research Triangle Park, NC 27709- 2137USASearch for other works by this author on:Robert A. Roth;Robert A. RothMichigan State UniversityDepartment of Pharmacology and Toxicology, East Lansing, MI 48824USASearch for other works by this author on:Melvin E. AndersenMelvin E. AndersenThe Hamner Institutes for Health SciencesProgram in Chemical Safety Sciences, Research Triangle Park, NC 27709- 2137USASearch for other works by this author on:
-
Chapter 25: Animal Models of Idiosyncratic, Drug-Induced Liver Injuryp642-664ByChristine M. Dugan;Christine M. DuganMichigan State UniversityCell and Molecular Biology Program, East Lansing, MI 48824USASearch for other works by this author on:Patricia E. Ganey;Patricia E. GaneyMichigan State UniversityDepartment of Pharmacology and Toxicology, Center for Integrative Toxicology, East Lansing, MI 48824USASearch for other works by this author on:Robert A. RothRobert A. RothMichigan State UniversityDepartment of Pharmacology and Toxicology, Center for Integrative Toxicology, East Lansing, MI 48824USASearch for other works by this author on:
Spotlight
Advertisement
Advertisement
