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Metallobiology
Gasotransmitters
Edited by
Rui Wang
Rui Wang
Laurentian University of Sudbury, Canada
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Hardback ISBN:
978-1-78262-924-5
PDF ISBN:
978-1-78801-300-0
EPUB ISBN:
978-1-78801-480-9
Special Collection:
2018 ebook collection
No. of Pages:
301
Publication date:
27 Jun 2018
Book Chapter
Chapter 3: Production of H2S – The l-cysteine/CSE-CBS-MST/H2S System
By
Yi Zhun Zhu
Yi Zhun Zhu
Department of Pharmacology, School of Pharmacy, Macau University of Science & Technology
Macau
China
yzzhu@must.edu.mo
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Published:27 Jun 2018
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Special Collection: 2018 ebook collection
Citation
Y. Z. Zhu, in Gasotransmitters, ed. R. Wang, The Royal Society of Chemistry, 2018, ch. 3, pp. 44-58.
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Hydrogen sulfide (H2S), a bioactive gasotransmitter, is produced endogenously primarily by three enzymes, cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MST). This chapter comprehensively reviews the characteristics, mechanisms, and potential regulation of H2S generation by the CSE/CBS/MST system. The production of polysulfide, the predominant form of H2S storage in vivo, is also discussed. In addition, exogenous H2S donors designed for mammalian cells are summarized and classified.
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