Ecotoxicology and Genotoxicology: Non-traditional Aquatic Models
Chapter 15: Genotoxicity in Urodele Amphibians Pleurodeles waltl and Ambystoma mexicanum (Lissamphibia, Caudata) Exposed to Freshwater Pollutants: A Historical View
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Published:05 Jul 2017
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Series: Issues in Toxicology
L. Gauthier and F. Mouchet, in Ecotoxicology and Genotoxicology: Non-traditional Aquatic Models, ed. M. L. Larramendy and M. L. Larramendy, The Royal Society of Chemistry, 2017, ch. 15, pp. 347-370.
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For a few decades, genotoxic aquatic environmental pollutants have been detected in vivo using mainly vertebrates like fish and amphibians. The chapter tells the story of the use of two non-model urodele amphibians, Pleurodeles waltl and Ambystoma mexicanum, for the design and development of a sensitive method for the detection of genotoxic effects in ecotoxicology. Since its inception in the late 1980s in Toulouse, France, the testing method has provided an internationally standardized protocol and has been used in various fields of research as diverse as public health, wastewater treatment, ecotoxicology and environmental genotoxicology, and more recently in functional ecology.
