Ecotoxicology and Genotoxicology: Non-traditional Aquatic Models intends to stimulate practical discussions on the use of non-conventional biotic matrices to address scientific challenges faced in these fields. It provides real-life examples to convey that the use of a non-conventional animal model, far from being a scientific conundrum, may instead provide real answers to some of our planet's problems. In this epilogue, we summarise the book and we hope that the importance of the status of the environment using autochthonous, non-target species, which are truly exposed to locally used xenobiotic agents, is realised.