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Advances in miniaturization technology derived from the microelectronics industry have facilitated the miniaturization of analytical devices. The assays embedded within miniaturized analytical devices utilize a range of detection technologies including electrochemical, colorimetric, and a range of luminescence detection technologies based on fluorescence, chemiluminescence, bioluminescence, and electrochemiluminescence. This chapter reviews the basics of micro-miniature analytical devices (microchips, lab-on-a-chip or micro total analytical systems) and surveys microchip-based assays that utilize chemiluminescence, bioluminescence, and electrochemiluminescence as the detection technology.

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