Emerging Drugs and Targets for Alzheimer's Disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose MetabolismCheck Access
Alzheimer's disease is the most prevalent neurodegenerative disorder in the elderly. A recent study from the Bloomberg School of Public Health recently estimated that over 26 million people were living with the disease in 2006 and that the global prevalence of the disease will grow to 106 million by 2050. By that time, 43 per cent of those living with the disease will need high-level care, equivalent to that of a nursing home. However, even if modest advances in preventing or delaying the disease's progression were made, it could have a huge impact on global public health. According to this study, interventions that could delay the onset of the disease by as little as one year would reduce the prevalence of the disease by 12 million fewer cases in 2050. These figures reinforce how important it is to find an effective intervention for Alzheimer's disease.
Emerging Drugs and Targets for Alzheimer's Disease collects some of the most outstanding examples of new drugs currently under pharmaceutical development or new targets in the validation process that will reach the Alzheimer's drug market over the next few years as disease modifying drugs. Written by a team of distinguished experts, these volumes are an essential resource for scientists in the pharmaceutical and biotechnology industries and academics working in the neurosciences field.
Emerging Drugs and Targets for Alzheimer's Disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism, The Royal Society of Chemistry, 2010.
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The Amyloid Hypothesis of Alzheimer's Disease and Prospects for Therapeuticsp3-18ByMichael S. WolfeMichael S. WolfeCenter for Neurologic Diseases77 Avenue Louis PasteurH.I.M. 754Brigham and Women's Hospital and Harvard Medical SchoolBostonMAUSASearch for other works by this author on:
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Chapter 2: Targeting Alzheimer's γ-Secretase: Genetic and Chemical Modulationp19-37ByWeiming XiaWeiming XiaCenter for Neurologic Diseases, Department of NeurologyBrigham and Women's HospitalHarvard Medical SchoolHarvard Institute of MedicineBostonMA 02115USASearch for other works by this author on:
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Chapter 3: Cholesterol and Alzheimer's Disease: The Molecules, the Targetsp38-58ByM. Dolores Ledesma;M. Dolores LedesmaCentro de Biología Molecular Severo OchoaCSIC-UAMNicolás Cabrera 128049MadridSpainSearch for other works by this author on:Carlos G. DottiCarlos G. DottiDepartment of Molecular and Developmental GeneticsVIBHerestrasse 493000 LeuvenBelgiumCenter for Human GeneticsK.U. LeuvenHerestrasse 493000 LeuvenBelgiumSearch for other works by this author on:
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Chapter 4: The Bimodal Features of Butyrylcholinesterase in Cholinergic Neurotransmission and Amyloid Suppressionp59-93ByErez Podoly;Erez PodolyWolfson Centre for Applied Structural Biology, Hebrew University of JerusalemGivat Ram91904JerusalemIsraelDepartment of Biological Chemistry, Hebrew University of JerusalemGivat Ram91904JerusalemIsraelSearch for other works by this author on:Hermona SoreqHermona SoreqDepartment of Biological Chemistry, Hebrew University of JerusalemGivat Ram91904JerusalemIsraelSearch for other works by this author on:
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Chapter 5: scyllo-Inositol: A Potential Therapeutic for Alzheimer's Diseasep94-116ByDaniela Fenili;Daniela FeniliDepartment of Laboratory Medicine and PathobiologyCentre for Research in Neurodegenerative DiseasesSearch for other works by this author on:Keran Ma;Keran MaDepartment of Laboratory Medicine and PathobiologyDepartment of Physiology, University of TorontoUniversity of Toronto6 Queen's Park Crescent WestTorontoOntarioCanadaM5S 3H2Search for other works by this author on:JoAnne McLaurinJoAnne McLaurinDepartment of Laboratory Medicine and PathobiologyCentre for Research in Neurodegenerative DiseasesSearch for other works by this author on:
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Chapter 6: Immunotherapeutic Strategies Towards Treatment of Alzheimer's Diseasep117-134ByBeka SolomonBeka SolomonProfessor of Biotechnology, Chair for Biotechnology of Neurodegenerative Diseases, Department of Molecular Microbiology & Biotechnology, George S. Wise Faculty of Life SciencesTel-Aviv UniversityIsraelSearch for other works by this author on:
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Chapter 7: Alzheimer Neurofibrillary Degeneration: Pivotal Role and Therapeutic Targetsp137-152ByKhalid Iqbal;Khalid IqbalDepartment of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities1050 Forest Hill RoadStaten IslandNew York10314USASearch for other works by this author on:Inge Grundke-IqbalInge Grundke-IqbalDepartment of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities1050 Forest Hill RoadStaten IslandNew York10314USASearch for other works by this author on:
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Chapter 8: Multiple Roles of Glycogen Synthase Kinase-3 in Alzheimer's Diseasep153-172ByMathieu Lesort;Mathieu LesortDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at BirminghamBirminghamAL 35294-0017USASearch for other works by this author on:Richard S. JopeRichard S. JopeDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at BirminghamBirminghamAL 35294-0017USASearch for other works by this author on:
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Chapter 9: Tau Protein Kinases Inhibitors: From the Bench to the Clinical Trialsp173-194ByDaniel I. Perez;Daniel I. PerezInstituto de Química Médica-CSICJuan de la Cierva 328006MadridSpainSearch for other works by this author on:Carmen Gil;Carmen GilInstituto de Química Médica-CSICJuan de la Cierva 328006MadridSpainSearch for other works by this author on:Ana MartinezAna MartinezInstituto de Química Médica-CSICJuan de la Cierva 328006MadridSpainSearch for other works by this author on:
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Chapter 10: Activating PP2A as a Therapeutic Intervention Strategy in Alzheimer's Diseasep195-209ByNiall M. Corcoran;Niall M. CorcoranDepartment of Surgery, Royal Melbourne Hospital, University of Melbourne5th Floor Clinical Sciences BldgParkvilleVIC 3050AustraliaSearch for other works by this author on:Christopher M. HovensChristopher M. HovensDepartment of Surgery, Royal Melbourne Hospital, University of Melbourne5th Floor Clinical Sciences BldgParkvilleVIC 3050AustraliaSearch for other works by this author on:
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Chapter 11: Rationale for Tau-Aggregation Inhibitor Therapy in Alzheimer's Disease and Other Tauopathiesp210-232ByClaude M. Wischik;Claude M. WischikTauRx Therapeutics Ltd. and School of Medicine and Dentistry, University of AberdeenForesterhillAberdeenAB25 2ZDScotlandUKSearch for other works by this author on:Damon J. Wischik;Damon J. WischikDepartment of Computer Science, University CollegeGower StreetLondonWC1E 6BTUKSearch for other works by this author on:John M.D. Storey;John M.D. StoreyTauRx Therapeutics Ltd. and Department of Chemistry, University of AberdeenMeston WalkAberdeenAB24 3UEScotlandUKSearch for other works by this author on:Charles R. HarringtonCharles R. HarringtonTauRx Therapeutics Ltd. and School of Medicine and Dentistry, University of AberdeenForesterhillAberdeenAB25 2ZDScotlandUKSearch for other works by this author on:
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Chapter 12: Insulin Resistance and Neurodegeneration: Type-2 Versus Type-3 Diabetes Mellitusp235-254BySuzanne M. de la Monte;Suzanne M. de la MonteDivisions of Neuropathology and Gastroenterology, Departments of Medicine, Pathology, and Neurology, and the Liver Research CenterRhode Island Hospital and the Warren Alpert Medical School of Brown UniversityProvidenceRIUSASearch for other works by this author on:Jack R. WandsJack R. WandsDivisions of Neuropathology and Gastroenterology, Departments of Medicine, Pathology, and Neurology, and the Liver Research CenterRhode Island Hospital and the Warren Alpert Medical School of Brown UniversityProvidenceRIUSASearch for other works by this author on:
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Chapter 13: Insulin-Like Growth Factor I as a Disease-Modifying Therapy in Alzheimer's Dementiap255-274ByAna M. Fernandez;Ana M. FernandezCajal InstituteCSIC and CIBERNEDAvda Dr. Arce 37Madrid28002SpainSearch for other works by this author on:Ignacio Torres-AlemanIgnacio Torres-AlemanCajal InstituteCSIC and CIBERNEDAvda Dr. Arce 37Madrid28002SpainSearch for other works by this author on:
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Chapter 14: Ketone Bodies as a Therapeutic for Alzheimer's Diseasep275-306BySamuel T. HendersonSamuel T. HendersonAccera, Inc.380 Interlocken CrescentSte. 780BroomfieldCO 80021USASearch for other works by this author on:
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