Comprehensive Biomarker Discovery and Validation for Clinical Application
Comprehensive Biomarker Discovery and Validation for Clinical Application provides the reader with an extensive introduction into all aspects of proteomics biomarker discovery, validation and development. It discusses the current status of science and technology, its limitations, bottlenecks as well as future development trends to improve the success rate of translating biomarker discovery into useful clinical tests. The most important feature of the book is to provide an overview of current technologies and the challenges encountered during biomarker discovery and validation, such as patient selection, sample handling, data processing, statistical analysis and registration and approval of validated biomarkers through European and US regulatory authorities. The authors introduce the reader to each of these topics in significant detail and provide examples or guidelines for best practice. There are prominent chapters included on biomarkers in translational and personalised medicine; an introduction to regulatory affairs and bring biomarkers to the market; biomarker discovery and the use of mass spectrometry based profiling platforms; MALDI imaging techniques in tissue-based biomarkers discovery and a clinical application study on the use of diagnostic assays for early diagnosis of heart failure using various proteomic methods. The book concludes with a final chapter on future trends in biomarker discovery and validation. The book targets a readership of industrial and academic researchers that are involved in biomarker discovery and validation or that manage biobanks, develop sample preparation methods, analytical profiling systems and bioinformatics tools. Common pitfalls and success stories in biomarker discovery are highlighted and guidelines for best practice are provided for the different parts of the procedure. The book will be an essential information resource for scientists working in the field.
Comprehensive Biomarker Discovery and Validation for Clinical Application, The Royal Society of Chemistry, 2013.
Download citation file:
Digital access
Print format
Table of contents
-
Introduction to Biomarker Discovery and ValidationByPéter Horvatovich;Péter HorvatovichAnalytical BiochemistryDepartment of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV GroningenThe NetherlandsNetherlands Bioinformatics CentreGeert Grooteplein 28, 6525 GA NijmegenThe NetherlandsSearch for other works by this author on:Rainer BischoffRainer BischoffAnalytical BiochemistryDepartment of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV GroningenThe NetherlandsNetherlands Bioinformatics CentreGeert Grooteplein 28, 6525 GA NijmegenThe NetherlandsSearch for other works by this author on:
-
CHAPTER 1: Introduction: Biomarkers in Translational and Personalized Medicinep3-39ByChanchal Kumar;Chanchal KumarTranslational Medicine Research Centre, Merck Research Laboratories, MSD8 Biomedical Grove, Neuros #04‐01, Singapore 138665SingaporeSearch for other works by this author on:Alain J. van GoolAlain J. van GoolTNO Quality of Health, Metabolic Health ResearchTNO, Zernikedreef 9, 2301 CE LeidenThe NetherlandsLaboratory of Genetic Endocrine and Metabolic Diseases, Department of Laboratory MedicineRadboud University Nijmegen Medical CenterThe Netherlands[email protected]Faculty of Physics, Mathematics and InformaticsRadboud University NijmegenThe NetherlandsSearch for other works by this author on:
-
CHAPTER 2: Introduction: Regulatory Development Hurdles for Biomarker Commercialization: The Steps Required to Get a Product to Marketp40-72ByMelissa A. ThompsonMelissa A. ThompsonMatrix Clinical Research Management, 59 Pine Street, Peterborough, NH 03458[email protected]Search for other works by this author on:
-
CHAPTER 3: Introduction: The Cardinal Role of Biobanks and Human Biospecimen Collections in Biomarker Validation: Issues Impeding Impact of Biomarker Research Outcomesp73-110ByAlain van GoolAlain van GoolTNO Quality of HealthMetabolic Health Research, Leidenthe Netherlandspascal.puchois@trans‐hit.com; [email protected]; [email protected]Laboratory of Genetic Endocrine and Metabolic Diseases, Department of Laboratory MedicineRadboud University Nijmegen Medical CenterThe NetherlandsFaculty of Physics, Mathematics and Informatics, Radboud University NijmegenThe NetherlandsSearch for other works by this author on:
-
CHAPTER 4: Sample Preparation and Profiling: Biomarker Discovery in Body Fluids by Proteomicsp113-135ByN. Govorukhina;N. GovorukhinaUniversity of Groningen, Centre of PharmacyAnalytical Biochemistry, Antonius Deusinglaan 1, 9713 AV GroningenThe Netherlands[email protected]Search for other works by this author on:R. BischoffR. BischoffUniversity of Groningen, Centre of PharmacyAnalytical Biochemistry, Antonius Deusinglaan 1, 9713 AV GroningenThe Netherlands[email protected]Search for other works by this author on:
-
CHAPTER 5: Sample Preparation and Profiling: Mass‐Spectrometry‐Based Profiling Strategiesp136-161ByYeoun Jin Kim;Yeoun Jin KimLuxembourg Clinical Proteomics Center, CRP-Santé1A-B rue Thomas EdisonL-1445 Strassen, Luxembourg[email protected][email protected]Search for other works by this author on:Bruno DomonBruno DomonLuxembourg Clinical Proteomics Center, CRP-Santé1A-B rue Thomas EdisonL-1445 Strassen, Luxembourg[email protected][email protected]Search for other works by this author on:
-
CHAPTER 6: Sample Preparation and Profiling: Probing the Kinome for Biomarkers and Therapeutic Targets: Peptide Arrays for Global Phosphorylation-Mediated Signal Transductionp162-195ByJason Kindrachuk;Jason KindrachukEmerging Viral Pathogens SectionNational Institute of Allergy and Infectious Diseases, National Institutes of Health, BethesdaMaryland, USA, 20892Search for other works by this author on:Scott Napper*Scott Napper*Department of BiochemistryUniversity of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5CanadaVaccine and Infectious Disease OrganizationUniversity of Saskatchewan, Saskatchewan, S7N 5E3Canada[email protected]Search for other works by this author on:
-
CHAPTER 7: Bioinformatics and Statistics: LC‐MS(/MS) Data Preprocessing for Biomarker Discoveryp199-225ByPéter Horvatovich;Péter HorvatovichAnalytical Biochemistry, Department of PharmacyUniversity of Groningen, A. Deusinglaan 1, 9713 AV GroningenThe NetherlandsNetherlands Bioinformatics CentreGeert Grooteplein 28, 6525 GA Nijmegenthe NetherlandsSearch for other works by this author on:Frank Suits;Frank SuitsIBM T.J. Watson Research Centre1101 Kitchawan Road, Yorktown Heights, 10598New York, USASearch for other works by this author on:Berend Hoekman;Berend HoekmanAnalytical Biochemistry, Department of PharmacyUniversity of Groningen, A. Deusinglaan 1, 9713 AV GroningenThe NetherlandsNetherlands Bioinformatics CentreGeert Grooteplein 28, 6525 GA Nijmegenthe NetherlandsSearch for other works by this author on:Rainer BischoffRainer BischoffAnalytical Biochemistry, Department of PharmacyUniversity of Groningen, A. Deusinglaan 1, 9713 AV GroningenThe NetherlandsNetherlands Bioinformatics CentreGeert Grooteplein 28, 6525 GA Nijmegenthe NetherlandsSearch for other works by this author on:
-
CHAPTER 8: Bioinformatics and Statistics: Statistical Analysis and Validationp226-242ByHuub C. J. HoefslootHuub C. J. HoefslootSearch for other works by this author on:
-
CHAPTER 9: Bioinformatics and Statistics: Computational Discovery, Verification, and Validation of Functional Biomarkersp243-268ByFan Zhang;Fan ZhangDepartment of Academic and Institutional Resources and TechnologyUniversity of North Texas Health Science Center, Fort WorthUSA[email protected]Department of Forensic and Investigative GeneticsUniversity of North Texas Health Science Center, Fort WorthUSASearch for other works by this author on:Renee DrabierRenee DrabierDepartment of Academic and Institutional Resources and TechnologyUniversity of North Texas Health Science Center, Fort WorthUSA[email protected]Search for other works by this author on:
-
CHAPTER 10: Discovery and Validation Case Studies, Recommendations: A Pipeline that Integrates the Discovery and Verification Studies of Urinary Protein Biomarkers Reveals Candidate Markers for Bladder Cancerp271-314ByYi‐Ting Chen;Yi‐Ting ChenMolecular Medicine Research CenterChang Gung University, Taoyuan 333TaiwanSearch for other works by this author on:Carol E. Parker;Carol E. ParkerUniversity of Victoria ‐ Genome BC Proteomics CentreUniversity of VictoriaVictoria, British Columbia, Canada[email protected]Search for other works by this author on:Hsiao‐Wei Chen;Hsiao‐Wei ChenMolecular Medicine Research CenterChang Gung University, Taoyuan 333TaiwanGraduate Institute of Biomedical SciencesCollege of Medicine, Chang Gung University, Taoyuan 333Taiwan[email protected]Search for other works by this author on:Chien‐Lun Chen;Chien‐Lun ChenChang Gung Bioinformatics Center, Department of UrologyChang Gung Memorial Hospital, Taoyuan 333TaiwanSearch for other works by this author on:Dominik Domanski;Dominik DomanskiUniversity of Victoria ‐ Genome BC Proteomics CentreUniversity of VictoriaVictoria, British Columbia, Canada[email protected]Search for other works by this author on:Derek S. Smith;Derek S. SmithUniversity of Victoria ‐ Genome BC Proteomics CentreUniversity of VictoriaVictoria, British Columbia, Canada[email protected]Search for other works by this author on:Chih‐Ching Wu;Chih‐Ching WuMolecular Medicine Research CenterChang Gung University, Taoyuan 333TaiwanGraduate Institute of Medical Biotechnology and Department of Medical Biotechnology and Laboratory ScienceChang Gung University, Taoyuan 333TaiwanSearch for other works by this author on:Ting Chung;Ting ChungMolecular Medicine Research CenterChang Gung University, Taoyuan 333TaiwanSearch for other works by this author on:Kung‐Hao Liang;Kung‐Hao LiangLiver Research CenterChang Gung Memorial Hospital, Taoyuan 333TaiwanSearch for other works by this author on:Min‐Chi Chen;Min‐Chi ChenGraduate Institute of Biomedical SciencesCollege of Medicine, Chang Gung University, Taoyuan 333Taiwan[email protected]Department of Public Health and Biostatistics Consulting CenterChang Gung University, Taoyuan 333TaiwanSearch for other works by this author on:Yu‐Sun Chang;Yu‐Sun ChangMolecular Medicine Research CenterChang Gung University, Taoyuan 333TaiwanGraduate Institute of Biomedical SciencesCollege of Medicine, Chang Gung University, Taoyuan 333Taiwan[email protected]Search for other works by this author on:Christoph H. Borchers;Christoph H. BorchersUniversity of Victoria ‐ Genome BC Proteomics CentreUniversity of VictoriaVictoria, British Columbia, Canada[email protected]Department of Biochemistry and MicrobiologyUniversity of Victoria, Victoria, BCCanadaSearch for other works by this author on:Jau‐Song YuJau‐Song YuMolecular Medicine Research CenterChang Gung University, Taoyuan 333TaiwanGraduate Institute of Biomedical SciencesCollege of Medicine, Chang Gung University, Taoyuan 333Taiwan[email protected]Search for other works by this author on:
-
CHAPTER 11: Discovery and Validation Case Studies, Recommendations: Discovery and Development of Multimarker Panels for Improved Prediction of Near‐Term Myocardial Infarctionp315-333ByPeter Juhasz;Peter JuhaszBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:Moira Lynch;Moira LynchBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:Manuel Paniagua;Manuel PaniaguaBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:Jennifer Campbell;Jennifer CampbellBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:Aram Adourian;Aram AdourianBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:Yu Guo;Yu GuoBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:Xiaohong Li;Xiaohong LiBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:Børge G. Nordestgaard;Børge G. NordestgaardDepartment of Clinical Biochemistry and the Copenhagen General Population StudyHerlev Hospital, Copenhagen University Hospital, CopenhagenDenmark[email protected]Search for other works by this author on:Neal F. GordonNeal F. GordonBG Medicine610N Lincoln St., Waltham, MA 02451USASearch for other works by this author on:
-
CHAPTER 12: Discovery and Validation Case Studies, Recommendations: Bottlenecks in Biomarker Discovery and Validation by Using Proteomic Technologiesp334-352ByMaria P. Pavlou;Maria P. PavlouDepartment of Pathology and Laboratory MedicineMount Sinai Hospital, Toronto, ONCanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, ONCanadaSearch for other works by this author on:Ivan M. Blasutig;Ivan M. BlasutigDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, ONCanadaDepartment of Clinical BiochemistryUniversity Health Network, Toronto, ONCanadaSearch for other works by this author on:Eleftherios P. DiamandisEleftherios P. DiamandisDepartment of Pathology and Laboratory MedicineMount Sinai Hospital, Toronto, ONCanadaDepartment of Laboratory Medicine and PathobiologyUniversity of Toronto, Toronto, ONCanadaDepartment of Clinical BiochemistryUniversity Health Network, Toronto, ONCanadaMount Sinai HospitalJoseph & Wolf Lebovic Ctr., 60 Murray St [Box 32], Flr 6 ‐ Rm L6‐201, Toronto, ON, M5T 3L9Canada[email protected]Search for other works by this author on:
Spotlight
Advertisement
Advertisement