Natural Product Chemistry for Drug Discovery
Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products. The authors, all experts in their respective fields, provide compelling arguments as to why naturel products should be considered important tools in the drug discovery process. The book will appeal across the board from scientists to professionals, postgraduates and industrial chemists. The case studies selected for inclusion highlight recently marketed drugs and development candidates that have been derived from natural products. These 'real-life' examples show how new technologies, such as advances in screening, isolation, dereplication and prefractionation, have significantly enhanced the discovery process.
Natural Product Chemistry for Drug Discovery, The Royal Society of Chemistry, 2009.
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Table of contents
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Chapter 1: Natural Products as Drugs and Leads to Drugs: The Historical Perspective1p3-27ByDavid J. Newman;David J. NewmanNatural Products Branch, Developmental Therapeutics Program, NCI-Frederick, PO Box B, FrederickMaryland21702USASearch for other works by this author on:Gordon M. CraggGordon M. CraggNatural Products Branch, Developmental Therapeutics Program, NCI-Frederick, PO Box B, FrederickMaryland21702USASearch for other works by this author on:
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Chapter 2: Chemical Space and the Difference Between Natural Products and Syntheticsp28-43BySheo B. Singh;Sheo B. SinghMerck Research LaboratoriesRahwayNJSearch for other works by this author on:J. Chris CulbersonJ. Chris CulbersonWest PointPAUSASearch for other works by this author on:
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Chapter 3: Mechanism of Action Studiesp44-78ByJames J. La ClairJames J. La ClairXenobe Research Institute3371 Adams AvenueSan DiegoCA 92116USASearch for other works by this author on:
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Chapter 4: The Convention on Biological Diversity and its Impact on Natural Product Researchp81-139ByGeoffrey A. CordellGeoffrey A. CordellNatural Products Inc.EvanstonIllinoisUSASearch for other works by this author on:
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Chapter 5: Plants: Revamping the Oldest Source of Medicines with Modern Science1p140-173ByGiovanni Appendino;Giovanni AppendinoIndena S.p.A.Viale Ortles 1220139 MilanoItalyUniversità del Piemonte Orientale, Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e FarmacologicheVia Bovio 628100 NovaraItalySearch for other works by this author on:Federica PollastroFederica PollastroUniversità del Piemonte Orientale, Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e FarmacologicheVia Bovio 628100 NovaraItalySearch for other works by this author on:
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Chapter 6: Macromarines: A Selective Account of the Potential of Marine Sponges, Molluscs, Soft Corals and Tunicates as a Source of Therapeutically Important Molecular Structuresp174-214ByJennifer Carroll;Jennifer CarrollDepartment of Chemistry and Biochemistry, California Polytechnic State UniversitySan Luis ObispoCalifornia 93407USASearch for other works by this author on:Phillip CrewsPhillip CrewsDepartment of Chemistry and Biochemistry and Institute for Marine Sciences, University of California Santa CruzSanta CruzCalifornia 95064USASearch for other works by this author on:
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Chapter 7: Microorganisms: Their Role in the Discovery and Development of Medicinesp215-241ByCedric Pearce;Cedric PearceMycosynthetix Inc505 Meadowlands Drive, Suite 103, HillsboroughNorth Carolina 27278USASearch for other works by this author on:Peter Eckard;Peter EckardBioFocus DPI AGGewerbestr. 16, CH-4123 AllschwilSwitzerlandSearch for other works by this author on:Iris Gruen-Wollny;Iris Gruen-WollnyLabor Gruen-WollnyVersailler Str.1, D-35394 GiessenGermanySearch for other works by this author on:Friedrich G. HansskeFriedrich G. HansskeBioFocus DPI AGGewerbestr. 16, CH-4123 AllschwilSwitzerlandSearch for other works by this author on:
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Chapter 8: Advances in Biological Screening for Lead Discoveryp243-271ByChristian N. Parker;Christian N. ParkerNovartis Institutes for BioMedical Research, Center for Proteomic ChemistryForum 1, Novartis CampusCH-4056BaselSwitzerlandSearch for other works by this author on:Johannes Ottl;Johannes OttlNovartis Institutes for BioMedical Research, Center for Proteomic ChemistryForum 1, Novartis CampusCH-4056BaselSwitzerlandSearch for other works by this author on:Daniela Gabriel;Daniela GabrielNovartis Institutes for BioMedical Research, Center for Proteomic ChemistryForum 1, Novartis CampusCH-4056BaselSwitzerlandSearch for other works by this author on:Ji-Hu ZhangJi-Hu ZhangNovartis Institutes for BioMedical Research, Center for Proteomic Chemistry250 Massachusetts AvenueCambridgeMA 02139USASearch for other works by this author on:
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Chapter 9: Advances in Instrumentation, Automation, Dereplication and Prefractionationp272-298ByTim S. Bugni*;Tim S. Bugni*University of Utah, Department of Medicinal Chemistry30 S. 2000 E. RM 307Salt Lake CityUT 84112USASearch for other works by this author on:Mary Kay Harper;Mary Kay HarperUniversity of Utah, Department of Medicinal Chemistry30 S. 2000 E. RM 307Salt Lake CityUT 84112USASearch for other works by this author on:Malcolm W.B. McCulloch;Malcolm W.B. McCullochUniversity of Utah, Department of Medicinal Chemistry30 S. 2000 E. RM 307Salt Lake CityUT 84112USASearch for other works by this author on:Emily L. WhitsonEmily L. WhitsonUniversity of Utah, Department of Medicinal Chemistry30 S. 2000 E. RM 307Salt Lake CityUT 84112USASearch for other works by this author on:
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Chapter 10: Natural Product Combinatorial Biosynthesis: Promises and Realitiesp299-317ByDaniel W. UdwaryDaniel W. UdwaryUniversity of Rhode Island41 Lower College DriveKingstonRI 02881USASearch for other works by this author on:
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Chapter 11: A Snapshot of Natural Product-Derived Compounds in Late Stage Clinical Development at the End of 2008p321-354ByMark S. ButlerMark S. ButlerMerLion Pharmaceuticals1 Science Park Road, The Capricorn #05-01, Singapore Science Park IISingapore117528Department of Chemistry, National University of SingaporeScience Drive 3Singapore117543Search for other works by this author on:
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Chapter 12: From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agentp355-373ByKin S. Lam;Kin S. LamNereus Pharmaceuticals, Inc.10480 Wateridge CircleSan DiegoCA 92121USASearch for other works by this author on:G. Kenneth Lloyd;G. Kenneth LloydNereus Pharmaceuticals, Inc.10480 Wateridge CircleSan DiegoCA 92121USASearch for other works by this author on:Saskia T. C. Neuteboom;Saskia T. C. NeuteboomNereus Pharmaceuticals, Inc.10480 Wateridge CircleSan DiegoCA 92121USASearch for other works by this author on:Michael A. Palladino;Michael A. PalladinoNereus Pharmaceuticals, Inc.10480 Wateridge CircleSan DiegoCA 92121USASearch for other works by this author on:Kobi M. Sethna;Kobi M. SethnaNereus Pharmaceuticals, Inc.10480 Wateridge CircleSan DiegoCA 92121USASearch for other works by this author on:Matthew A. Spear;Matthew A. SpearNereus Pharmaceuticals, Inc.10480 Wateridge CircleSan DiegoCA 92121USASearch for other works by this author on:Barbara C. PottsBarbara C. PottsNereus Pharmaceuticals, Inc.10480 Wateridge CircleSan DiegoCA 92121USASearch for other works by this author on:
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Chapter 13: From Natural Product to Clinical Trials: Bevirimat, a Plant-Derived Anti-AIDS Drug1p374-391ByKeduo Qian;Keduo QianNatural Products Research Laboratories, Eshelman School of Pharmacy, University of North CarolinaChapel HillNC 27599USASearch for other works by this author on:Theodore J. Nitz;Theodore J. NitzPanacos Pharmaceuticals Inc.209 Perry ParkwayGaithersburgMD 20878USASearch for other works by this author on:Donglei Yu;Donglei YuNatural Products Research Laboratories, Eshelman School of Pharmacy, University of North CarolinaChapel HillNC 27599USASearch for other works by this author on:Graham P. Allaway;Graham P. AllawayPanacos Pharmaceuticals Inc.209 Perry ParkwayGaithersburgMD 20878USASearch for other works by this author on:Susan L. Morris-Natschke;Susan L. Morris-NatschkeNatural Products Research Laboratories, Eshelman School of Pharmacy, University of North CarolinaChapel HillNC 27599USASearch for other works by this author on:Kuo-Hsiung LeeKuo-Hsiung LeeNatural Products Research Laboratories, Eshelman School of Pharmacy, University of North CarolinaChapel HillNC 27599USASearch for other works by this author on:
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Chapter 14: Daptomycinp395-409ByRichard H. BaltzRichard H. BaltzCubist Pharmaceuticals, Inc.LexingtonMA 02421USASearch for other works by this author on:
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Chapter 15: Micafunginp410-428ByAkihiko Fujie;Akihiko FujieFermentation Research Labs, Astellas Pharma Inc.5-2-3, Tokodai, TsukubaIbaraki 300-2698JapanSearch for other works by this author on:Shuichi Tawara;Shuichi TawaraFermentation Research Labs, Astellas Pharma Inc.5-2-3, Tokodai, TsukubaIbaraki 300-2698JapanSearch for other works by this author on:Seiji HashimotoSeiji HashimotoToyama Prefectural University5180 Kurokawa, ImizuToyama 939-0398JapanSearch for other works by this author on:
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