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Drug Discovery
Biotherapeutics: Recent Developments using Chemical and Molecular Biology
Edited by
Andrew J McKnight
Andrew J McKnight
AnaptysBio Inc., USA
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Hardback ISBN:
978-1-84973-601-5
PDF ISBN:
978-1-84973-715-9
Special Collection:
2013 ebook collection
,
2011-2015 industrial and pharmaceutical chemistry subject collection
Series:
Drug Discovery
No. of Pages:
336
Published online:
06 Sep 2013
Published in print:
17 Sep 2013
About this book
This book illustrates the successful partnership of chemistry and biology to advance successful biotherapeutic modalities. Molecular design to create function is common to both chemical and molecular biology, and this text highlights recent developments from these disciplines that have delivered drugs, clinical candidates or significantly advanced biotherapeutic approaches.
Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area, by explaining and describing the chemical biology technologies that underpin specific therapeutic advances and demonstrating the unique value of molecular design and understanding.
Covering topics such as selective protein modification, immunopharmacotherapy, chemically programmed vaccinations, nanobodies and antibodies, this book provides essential reading for medicinal and pharmaceutical chemists working in both industry and academia.
Biotherapeutics: Recent Developments using Chemical and Molecular Biology, The Royal Society of Chemistry, 2013.
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Digital access
$224.00
Print format
Biotherapeutics
$224.00
Table of contents
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Synthetic Immunologyp1-35ByThihan R. Padukkavidana;Thihan R. PadukkavidanaDepartment of ChemistryYale University, 225 Prospect Street, PO Box 208107, New Haven, CT 06520-8107USASearch for other works by this author on:Patrick J. M cEnaney;Patrick J. M cEnaneyDepartment of ChemistryYale University, 225 Prospect Street, PO Box 208107, New Haven, CT 06520-8107USASearch for other works by this author on:David A. SpiegelDavid A. SpiegelDepartment of ChemistryYale University, 225 Prospect Street, PO Box 208107, New Haven, CT 06520-8107USADepartment of PharmacologyYale University School of Medicine, 333 Cedar Street, SHM B350B, New Haven, CT 06520USA[email protected]Search for other works by this author on:
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CHAPTER 2: Immunopharmacotherapy for Nicotine Addictionp36-67ByJonathan W. Lockner;Jonathan W. LocknerDepartment of ChemistryThe Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037USA[email protected]Search for other works by this author on:Kim D. JandaKim D. JandaDepartment of ChemistryThe Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037USA[email protected]Search for other works by this author on:
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CHAPTER 3: Carbohydrate Vaccinesp68-104ByBenjamin Schumann;Benjamin SchumannMax Planck Institute of Colloids and Interfaces14424 PotsdamGermanySearch for other works by this author on:Chakkumkal Anish;Chakkumkal AnishMax Planck Institute of Colloids and Interfaces14424 PotsdamGermanySearch for other works by this author on:Claney L. Pereira;Claney L. PereiraMax Planck Institute of Colloids and Interfaces14424 PotsdamGermanySearch for other works by this author on:Peter H. SeebergerPeter H. SeebergerMax Planck Institute of Colloids and Interfaces14424 PotsdamGermanySearch for other works by this author on:
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CHAPTER 4: Generation and Maturation of Therapeutic Antibodies via In Vitro Somatic Hypermutationp105-129ByDavid J. KingDavid J. KingSearch for other works by this author on:
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CHAPTER 5: Synthetic Protein Biologicsp130-144ByBenjamin G. DavisBenjamin G. DavisDepartment of ChemistryUniversity of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TAUK[email protected]Search for other works by this author on:
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CHAPTER 6: Recent Advances in Antibody–Drug Conjugatesp145-175ByEdmund I. Graziani;Edmund I. GrazianiOncology Medicinal ChemistryPfizer Global Research, 445 Eastern Point Road, Groton CT 06340USA[email protected]Search for other works by this author on:L. Nathan TumeyL. Nathan TumeyOncology Medicinal ChemistryPfizer Global Research, 445 Eastern Point Road, Groton CT 06340USA[email protected]Search for other works by this author on:
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CHAPTER 7: MicroRNA Biotherapeutics: Key Challenges from a Drug Development Perspectivep176-223BySterghios Athanasios MoschosSterghios Athanasios MoschosDepartment of Molecular and Applied BiosciencesSchool of Life Sciences, University of Westminster, 115 New Cavendish Street, London, W1W 6UWUK[email protected]Search for other works by this author on:
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CHAPTER 8: Novel Therapeutic Agents from Bacterial Toxinsp224-240ByJohn A. ChaddockJohn A. ChaddockSearch for other works by this author on:
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CHAPTER 9: Phage Selection of Mono- and Bicyclic Peptide Ligandsp241-262ByShiyu Chen;Shiyu ChenInstitute of Chemical Sciences and EngineeringEcole Polytechnique Fédérale de Lausanne, CH-1015 LausanneSwitzerland[email protected]Search for other works by this author on:Christian HeinisChristian HeinisInstitute of Chemical Sciences and EngineeringEcole Polytechnique Fédérale de Lausanne, CH-1015 LausanneSwitzerland[email protected]Search for other works by this author on:
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CHAPTER 10: Chemical Approaches for Localization, Characterization and Mimicry of Peptide Epitopesp263-284ByPaul R. Werkhoven;Paul R. WerkhovenMedicinal Chemistry and Chemical BiologyUtrecht University, Universiteitsweg 99, 3584 CG Utrecht, 3508 TB UtrechtThe NetherlandsSearch for other works by this author on:Rob M.J. LiskampRob M.J. LiskampMedicinal Chemistry and Chemical BiologyUtrecht University, Universiteitsweg 99, 3584 CG Utrecht, 3508 TB UtrechtThe NetherlandsSchool of ChemistryJoseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQUK[email protected]Search for other works by this author on:
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CHAPTER 11: Cystine-Knot Micro-Proteinsp285-297ByDuncan McGregorDuncan McGregorSearch for other works by this author on:
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