Human-based Systems for Translational Research
This book provides a history and discussion of the use of human tissues as an alternative to animal-based testing for assessing the efficacy and safety of new medicines. Beginning by providing a historical background to animal-based testing, this text then describes in detail the issues relating to access to human cells and tissue and the rules and regulations governing their use. The book illustrates what is currently possible in humanising medicines research and development, and suggests more rational and reliable means of developing safe and effective drugs for the future than those on which we currently rely. Early chapters establish the need to generate more data in human-derived test systems, and the need for resources such as tissue banks and standardised processes whilst highlighting the barriers that have prevented such developments so far. Subsequent chapters explore the alternatives to current animal toxicology studies, including stem cells and computational models, with balanced views of the technical challenges and opportunities these offer. In addition, useful information on computational methods and pharmacokinetics are included. This book is an essential read for anyone engaged in translational drug discovery who wishes to consolidate their understanding and broaden their awareness of the key issues involved in accessing primary human tissue and the advantages of doing so.
Human-based Systems for Translational Research, The Royal Society of Chemistry, 2014.
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Table of contents
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Access to Human Cells and Tissuesp1-16ByGerry ThomasGerry ThomasDepartment of Surgery and Cancer, Imperial College LondonRoom 11L05Charing Cross HospitalFulham Palace RoadLondon W6 8RFUK[email protected]Search for other works by this author on:
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Chapter 2: Functional Studies with Human Isolated Tissues to Better Predict Clinical Safety and Efficacyp17-37ByDavid C. BuntonDavid C. BuntonSearch for other works by this author on:
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Chapter 3: Translational Research in Pharmacology and Toxicology Using Precision-Cut Tissue Slicesp38-65ByG. M. M. Groothuis;G. M. M. GroothuisDivision of Pharmacokinetics, Toxicology & Targeting, Department of Pharmacy, University of GroningenA. Deusinglaan 19713 AV Groningenthe Netherlands[email protected]Search for other works by this author on:A. Casini;A. CasiniDivision of Pharmacokinetics, Toxicology & Targeting, Department of Pharmacy, University of GroningenA. Deusinglaan 19713 AV Groningenthe Netherlands[email protected]Search for other works by this author on:H. Meurs;H. MeursDivision of Molecular Pharmacology, Department of Pharmacy, University of GroningenA. Deusinglaan 19713 AV Groningenthe NetherlandsSearch for other works by this author on:P. OlingaP. OlingaDivision of Pharmaceutical Technology & Biopharmacy, Department of Pharmacy, University of GroningenA. Deusinglaan 19713 AV Groningenthe NetherlandsSearch for other works by this author on:
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Chapter 4: Modelling the Human Respiratory System: Approaches for in Vitro Safety Testing and Drug Discoveryp66-87ByZoë Prytherch;Zoë PrytherchSchool of Biosciences, Cardiff UniversityThe Sir Martin Evan BuildingMuseum AvenueCardiff CF10 3AXWalesUK[email protected]Search for other works by this author on:Kelly BérubéKelly BérubéSchool of Biosciences, Cardiff UniversityThe Sir Martin Evan BuildingMuseum AvenueCardiff CF10 3AXWalesUK[email protected]Search for other works by this author on:
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Chapter 5: Complex Primary Human Cell Systems for Drug Discoveryp88-109ByEllen L. Berg;Ellen L. BergBioSeek, A Division of DiscoveRx310 Utah AvenueSuite 100South San FranciscoCA 94080USA[email protected]Search for other works by this author on:Alison O'MahonyAlison O'MahonyBioSeek, A Division of DiscoveRx310 Utah AvenueSuite 100South San FranciscoCA 94080USA[email protected]Search for other works by this author on:
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Chapter 6: Human in Vitro ADMET and Prediction of Human Pharmacokinetics and Toxicity Liabilities at the Discovery Stagep110-131ByKatya TsaiounKatya TsaiounSearch for other works by this author on:
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Chapter 7: ‘Body-on-a-Chip’ Technology and Supporting Microfluidicsp132-161ByJ. J. HickmanJ. J. HickmanSearch for other works by this author on:
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Chapter 8: Utility of Human Stem Cells for Drug Discoveryp162-193BySatyan Chintawar;Satyan ChintawarNuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordOxford OX3 9DUUK[email protected]Search for other works by this author on:Martin Graf;Martin GrafRoche Pharmaceutical Research and Early Development, Discovery Technologies, Roche Innovation Center Basel124 GrenzacherstrasseCH 4070 BaselSwitzerlandSearch for other works by this author on:Zameel CaderZameel CaderNuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of OxfordOxford OX3 9DUUK[email protected]Search for other works by this author on:
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Chapter 9: In Silico Solutions for Predicting Efficacy and Toxicityp194-218ByKevin P. CrossKevin P. CrossSearch for other works by this author on:
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Chapter 10: In Silico Organ Modelling in Predicting Efficacy and Safety of New Medicinesp219-240ByBlanca RodriguezBlanca RodriguezSearch for other works by this author on:
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Chapter 11: Human Microdosing/Phase 0 Studies to Accelerate Drug Developmentp241-266ByR. Colin GarnerR. Colin GarnerSearch for other works by this author on:
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