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Dopamine‐replacement therapy still stands as the most effective pharmacological strategy for the management of motor impairment associated with Parkinson’s disease. The present chapter aims to provide an overview of the pharmacology of dopamine‐replacement therapy in both preclinical experimental models of Parkinson’s disease and patients, and to present its light and shadows. The effect of dopamine‐replacement therapy on motor impairment, motor complications, non‐motor symptoms, and disease progression will be discussed, with a focus on future therapeutic directions.

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