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The Handbook of Medicinal Chemistry: Principles and Practice
Edited by
Simon E Ward
Simon E Ward
Cardiff University, UK
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Hardback ISBN:
978-1-84973-625-1
PDF ISBN:
978-1-78262-183-6
EPUB ISBN:
978-1-78262-419-6
Special Collection:
RSC eTextbook Collection
Product Type:
Textbooks
No. of Pages:
753
Publication date:
09 Dec 2014
About this book
Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery.
Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development.
The Handbook of Medicinal Chemistry: Principles and Practice, The Royal Society of Chemistry, 2014.
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Digital access
$119.00
Table of contents
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CHAPTER 1: Physicochemical Properties and Compound Qualityp1-31ByM. Paul Gleeson;M. Paul GleesonDepartment of Chemistry, Faculty of Science, Kasetsart University50 Phaholyothin Rd, ChatuchakBangkok10900Thailand[email protected]Search for other works by this author on:Paul D. Leeson;Paul D. LeesonGlaxoSmithKline Medicines Research CentreGunnels Wood Road, StevenageHertfordshireSG1 2NYUnited Kingdom[email protected][email protected]Search for other works by this author on:Han van de WaterbeemdHan van de WaterbeemdSearch for other works by this author on:
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CHAPTER 2: Parallel Synthesis and Library Designp32-65ByAndy MerrittAndy MerrittMRCT Centre for Therapeutics Discovery1-3 Burtonhole Lane, Mill HillLondonNW7 1ADUK[email protected]Search for other works by this author on:
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CHAPTER 3: Useful Computational Chemistry Tools for Medicinal Chemistryp66-95ByDarren V. S. GreenDarren V. S. GreenGlaxoSmithKline Medicines Research CentreGunnels Wood RoadStevenage, HertfordshireSG1 2NYUK[email protected]Search for other works by this author on:
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CHAPTER 4: Structure-Based Design for Medicinal Chemistsp96-121ByAndrew M. DavisAndrew M. DavisAstraZeneca Respiratory and Inflammation Innovative MedicinesPepparedsleden 1 Mölndal,43183SwedenSearch for other works by this author on:
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CHAPTER 5: Fragment Based Lead Discoveryp122-153ByRoderick E. HubbardRoderick E. HubbardYSBL, University of YorkHeslingtonYorkYO10 5DDUKSearch for other works by this author on:
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CHAPTER 6: Quantitative Structure–Activity Relationshipsp154-183ByAndrew M. DavisAndrew M. DavisRespiratory Inflammation and Immunity Innovative Medicines, AstraZeneca R&D MölndalPepparedsleden 1Mölndal43183Sweden[email protected]Search for other works by this author on:
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CHAPTER 7: Drug Metabolismp184-207ByC. W. Vose;C. W. VoseCVFV Consulting. Address at time of writing: Centre for Integrated Drug Development, Quintiles Ltd500 Brook Drive, Green Park, ReadingBerkshireRG2 6UUUnited Kingdom[email protected]Search for other works by this author on:R. M. J. IngsR. M. J. IngsRMI-Pharmacokinetics1317, Bulrush CtCarlsbadCA 92011USASearch for other works by this author on:
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CHAPTER 8: Prediction of Human Pharmacokinetics, Exposure and Therapeutic Dose in Drug Discoveryp208-238ByDermot F. McGinnity;Dermot F. McGinnityDMPK, Drug Safety and MetabolismAstraZenecaMölndalSwedenSearch for other works by this author on:Ken Grime;Ken GrimeDMPK, Respiratory, Inflammation and Autoimmune IMedAstraZenecaMölndalSwedenSearch for other works by this author on:Peter J. H. WebbornPeter J. H. WebbornSearch for other works by this author on:
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CHAPTER 9: Molecular Biology for Medicinal Chemistsp239-265ByAli JazayeriAli JazayeriSearch for other works by this author on:
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CHAPTER 10: Assaysp266-291ByTim Hammonds;Tim HammondsCancer Research Technology Ltd, Wolfson Institute for Biomedical ResearchCruciform Building, Gower StreetLondonWC1E 6BTUK[email protected]Search for other works by this author on:Peter B. SimpsonPeter B. SimpsonDiscovery Sciences, AstraZenecaAlderley ParkCheshireSK10 4TGUKSearch for other works by this author on:
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CHAPTER 11: In Vitro Biology: Measuring Pharmacological Activityp292-309ByIain G. DougallIain G. DougallSearch for other works by this author on:
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CHAPTER 12: Animal Models: Practical Use and Considerationsp310-335ByRobbie L. McLeodRobbie L. McLeodSearch for other works by this author on:
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CHAPTER 13: Bioinformatics for Medicinal Chemistryp336-349ByNiklas Blomberg;Niklas BlombergELIXIR HubWellcome Trust Genome CampusHinxtonCambridge CB10 1SDUKSearch for other works by this author on:Bryn Williams-Jones;Bryn Williams-JonesConnectedDiscovery Ltd.27 Old Gloucester StreetLondonWC1N 3AXUKSearch for other works by this author on:John P. OveringtonJohn P. OveringtonEuropean Bioinformatics Institute (EMBL-EBI), European Molecular Biology LaboratoryWellcome Trust Genome CampusHinxtonCambridge CB10 1SDUK[email protected]Search for other works by this author on:
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CHAPTER 14: Translational Sciencep350-363ByAlasdair J. GawAlasdair J. GawDepartment of Health+Care, Technology Strategy BoardNorth Star House, North StarSwindonSN2 1UEUK[email protected]Search for other works by this author on:
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CHAPTER 15: Discovery Toxicology In Lead Optimisationp364-412ByCaterina VirginioCaterina VirginioSearch for other works by this author on:
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CHAPTER 16: Toxicology and Drug Developmentp413-423ByMark W. PowleyMark W. PowleyU.S. Food and Drug Administration, Division of Antiviral ProductsWO22 RM6373, 10903 New Hampshire Ave.Silver SpringMD 20993USA[email protected]Search for other works by this author on:
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CHAPTER 17: Patents for Medicinesp424-455ByPaul A. Brady;Paul A. BradyAbel & Imray Patent Attorneys20 Red Lion StreetLondonWC1R 4PQUnited KingdomSearch for other works by this author on:Gordon WrightGordon WrightElkington and Fife LLPProspect House, 8 Pembroke Road, SevenoaksKentTN13 1XRUnited KingdomSearch for other works by this author on:
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CHAPTER 18: The Modern Drug Discovery Processp456-485ByMark C. NoeMark C. NoeSearch for other works by this author on:
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CHAPTER 19: Target Validation for Medicinal Chemistsp486-504ByPaul Beswick;Paul BeswickTranslational Drug Discovery GroupUniversity of Sussex, BrightonEast SussexBN1 9QJUK[email protected]Search for other works by this author on:Keith BowersKeith BowersBiopta Ltd., Weipers CentreGarscube Estate, Bearsden RoadGlasgowG61 1QHUKSearch for other works by this author on:
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CHAPTER 20: Lead Generationp505-528ByJohn SteeleJohn SteeleSearch for other works by this author on:
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CHAPTER 21: Lead Optimisation: What You Should Know!p529-565ByStephen Connolly;Stephen ConnollyScientific Leader, Medicinal ChemistryAlmirall R&D, 08980 Sant Feliu de LlobregatBarcelonaSpain[email protected]Search for other works by this author on:Simon E. WardSimon E. WardProfessor of Medicinal Chemistry and Director of Translational Drug Discovery Group, University of SussexBrightonBN1 9QJUnited Kingdom[email protected]Search for other works by this author on:
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CHAPTER 22: Pharmaceutical Properties—the Importance of Solid Form Selectionp566-591ByNicola ClearNicola ClearSearch for other works by this author on:
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CHAPTER 23: The Chemical Development and Medicinal Chemistry Interfacep592-602ByDavid EnnisDavid EnnisAstraZenecaCharter Way, Silk Road Business Park, MacclesfieldCheshireSK10 2NXUKSearch for other works by this author on:
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CHAPTER 24: Project Managementp603-622ByPauline Stewart-LongPauline Stewart-LongSearch for other works by this author on:
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CHAPTER 25: Clinical Drug Developmentp623-632ByMaarten KraanMaarten KraanSearch for other works by this author on:
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CHAPTER 26: Aleglitazar: A Case Studyp633-675ByPeter MohrPeter MohrRoche Pharmaceutical Research & Early Development, Small Molecule ResearchRoche Innovation CenterBaselSwitzerland[email protected]Search for other works by this author on:
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CHAPTER 27: Lessons Learned From the Discovery and Development of Lapatinib/Tykerbp676-698ByG. Stuart Cockerill;G. Stuart CockerillSchool of Medicine, Pharmacy and Health, Wolfson Research InstituteQueens Campus, Durham UniversityStockton-on-TeesTS17 6BHUK[email protected]Search for other works by this author on:Karen E. LackeyKaren E. LackeyCenter for Drug Discovery at Medical University of South Carolina171 Ashley AveCharlestonSC 29425USASearch for other works by this author on:
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CHAPTER 28: “Daring to be Different”: The Discovery of Ticagrelorp699-714ByBob Humphries;Bob HumphriesVisionRealisation LtdLeicestershireUKSearch for other works by this author on:John DixonJohn DixonSearch for other works by this author on:
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