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Lead Optimisation (LO) is a critical part of the drug discovery process as it is the part where all efforts that go into earlier parts of the process (Target Identification, HTS, Hit-to-Lead, Lead Identification) are crystallised into a single compound, the candidate drug. The optimization phase is like a treasure hunt, and discovery projects can take many paths to discover their treasured molecule. In this Chapter we have chosen to focus on the practicalities of how the LO project can be organized, and what different property issues the project may face as it attempts to find an efficient path forward to find a suitable candidate drug for Development. This multiparameter optimization dance can have many issues, often interconnected. We discuss approaches to many of these problems, and offer advice on how project members should think about tackling issues in a holistic way. In this way we hope to support projects in understanding the right issues to tackle at the right time. We offer some tips, and examples, of successes, and suggest that identifying the issue to tackle is key to establishing robust hypotheses to test and so drive projects forwards. Our goal in this Chapter is to aid project thinking about the best way forward.

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