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Successful Strategies for the Discovery of Antiviral Drugs

RSC Drug Discovery Series

Editor-in-Chief:

Professor David E. Thurston, King's College, London, UK

Series Editors:

Dr David Fox, Vulpine Science and Learning, UK

Professor Ana Martinez, Instituto de Quimica Medica-CSIC, Spain

Professor David Rotella, Montclair State University, USA

Advisor to the Board:

Professor Robin Ganellin, University College London, UK

Titles in the Series:

舁1: Metabolism, Pharmacokinetics and Toxicity of Functional Groups

舁2: Emerging Drugs and Targets for Alzheimer's Disease; Volume 1

舁3: Emerging Drugs and Targets for Alzheimer's Disease; Volume 2

舁4: Accounts in Drug Discovery

舁5: New Frontiers in Chemical Biology

舁6: Animal Models for Neurodegenerative Disease

舁7: Neurodegeneration

舁8: G Protein-Coupled Receptors

舁9: Pharmaceutical Process Development

10: Extracellular and Intracellular Signaling

11: New Synthetic Technologies in Medicinal Chemistry

12: New Horizons in Predictive Toxicology

13: Drug Design Strategies: Quantitative Approaches

14: Neglected Diseases and Drug Discovery

15: Biomedical Imaging

16: Pharmaceutical Salts and Cocrystals

17: Polyamine Drug Discovery

18: Proteinases as Drug Targets

19: Kinase Drug Discovery

20: Drug Design Strategies: Computational Techniques and Applications

21: Designing Multi-Target Drugs

22: Nanostructured Biomaterials for Overcoming Biological Barriers

23: Physico-Chemical and Computational Approaches to Drug Discovery

24: Biomarkers for Traumatic Brain Injury

25: Drug Discovery from Natural Products

26: Anti-Inflammatory Drug Discovery

27: New Therapeutic Strategies for Type 2 Diabetes: Small Molecules

28: Drug Discovery for Psychiatric Disorders

29: Organic Chemistry of Drug Degradation

30: Computational Approaches to Nuclear Receptors

31: Traditional Chinese Medicine

32: Successful Strategies for the Discovery of Antiviral Drugs

How to obtain future titles on publication:

A standing order plan is available for this series. A standing order will bring delivery of each new volume immediately on publication.

For further information please contact:

Book Sales Department, Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UKTelephone: +44 (0)1223 420066, Fax: +44 (0)1223 420247, Email: [email protected]

Visit our website at www.rsc.org/books

Successful Strategies for the Discovery of Antiviral Drugs

Edited by

Manoj C. Desai

Gilead Science Inc., Foster City, California, USA

Nicholas A. Meanwell

Bristol-Myers Squibb Research, Wallingford, Connecticut, USA

graphic

RSC Drug Discovery Series No. 32

ISBN: 978-1-84973-657-2

ISSN: 2041-3203

A catalogue record for this book is available from the British Library

© The Royal Society of Chemistry 2013

All rights reserved

Apart from fair dealing for the purposes of research for non-commercial purposes or for private study, criticism or review, as permitted under the Copyright, Designs and Patents Act 1988 and the Copyright and Related Rights Regulations 2003, this publication may not be reproduced, stored or transmitted, in any form or by any means, without the prior permission in writing of The Royal Society of Chemistry or the copyright owner, or in the case of reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page.

The RSC is not responsible for individual opinions expressed in this work.

Published by The Royal Society of Chemistry,

Thomas Graham House, Science Park, Milton Road,

Cambridge CB4 0WF, UK

Registered Charity Number 207890

For further information see our web site at www.rsc.org

Printed in the United Kingdom by Henry Ling Limited, Dorchester, DT1 1HD, UK

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