Chapter 8: Prolinol Silyl Ethers as Asymmetric Organocatalysts
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Published:16 Nov 2015
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Special Collection: 2015 ebook collection , ECCC Environmental eBooks 1968-2022 , 2011-2015 physical chemistry subject collectionSeries: Green Chemistry Series
R. Šebesta and Z. Sorádová, in Sustainable Catalysis: Without Metals or Other Endangered Elements, Part 1, ed. M. North and M. North, The Royal Society of Chemistry, 2015, ch. 8, pp. 166-199.
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Prolinol silyl ethers are one of the prominent catalyst core structures in asymmetric organocatalysis. These catalysts are able to activate carbonyl compounds via enamine formation or α,β-unsaturated carbonyls via iminium ion formation. Prolinol silyl ethers are useful for a range of Michael additions and domino reactions based on 1,4-additions. Furthermore, cycloadditions, Mannich reactions, α-functionalisation and other reactions are also enhanced by these catalysts. There are also several examples in which greener solvents were used in such reactions.
