Asymmetric Autocatalysis: The Soai Reaction
Chapter 12: Structure Analysis of Asymmetric Autocatalysis by X-ray Crystallography and Circular Dichroism Spectroscopy
Published:28 Oct 2022
A. Matsumoto, T. Kawasaki, and K. Soai, in Asymmetric Autocatalysis: The Soai Reaction, ed. K. Soai, T. Kawasaki, and A. Matsumoto, The Royal Society of Chemistry, 2022, ch. 12, pp. 273-288.
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The asymmetric autocatalysis of pyrimidylalkanols is an extremely distinctive reaction that can induce significant asymmetric amplification in a simple self-replication reaction. As asymmetric amplification is the key to unraveling the mystery of homochirality, the mechanism of this reaction has attracted considerable attention over a long time. Numerous studies aimed at elucidating the mechanism of this reaction have revealed that the aggregation of zinc alkoxides plays an important role in asymmetric amplification. In this chapter, we introduce the various aggregation forms of pyrimidylalkanol zinc alkoxides, as revealed by single-crystal X-ray diffraction analysis, and discuss their relationship to other mechanistic studies, as well as the study of the equilibrium of aggregation states in solution by circular dichroism spectroscopy.