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Amphiphilic compounds and in particular phospholipids are supposed to play principally only a structural role, however they represent an evolutionary and non-negligible step in life emergence. Progress in the past decades with the advent of systems chemistry approaches has led to a deeper understanding of these unique hydrophobic molecules and their roles in biochemistry. Today the growing interest in “prebiotic lipidomics” calls for a new assessment of these relevant biomolecules.

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