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Facing the bioaccumulative issue related to long-chain perfluoroalkyl substances, this chapter summarizes current research on promising alternative candidates based on fluoroethers. Recent studies include the synthesis of anionic, cationic and amphoteric fluorinated surfactants and their properties. Environmental and biological effects have been recorded for some of these fluoroether surfactants. Although the data are still limited, it is hoped that this chapter could inspire future design strategies.

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