Nanotechnology for Diabetes Management
Chapter 2: Epigenomics of Type 2 Diabetes
Published:19 Sep 2022
Special Collection: 2022 ebook collectionSeries: Nanoscience & Nanotechnology
A. N. Parveen and B. S. Dhawan, in Nanotechnology for Diabetes Management, ed. A. Abderrahmani, S. Szunerits, R. Boukerroub, and A. El Ouaamari, The Royal Society of Chemistry, 2022, ch. 2, pp. 53-91.
Download citation file:
This chapter covers the advances made in epigenomics of type 2 diabetes, and how such work has elucidated the epigenetic underpinnings of this disease and its multiple complications. It discusses the developmental basis of diabetes, the causal role of gene–environment interactions in diabetes risk and pathogenesis, epigenetic dysregulation in multiple metabolic tissues, and the nanobiology of cell–cell communication in perpetuating such disease-relevant epigenetic changes. Finally, it delves into the translational potential of such studies on the development of biomarkers and therapeutic approaches for type 2 diabetes.