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Nanoscience & Nanotechnology Series
Nanotechnology for Diabetes Management
Edited by
Amar Abderrahmani;
Amar Abderrahmani
University of Lille, France
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Sabine Szunerits;
Sabine Szunerits
University of Lille, France
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Rabah Boukerroub;
Rabah Boukerroub
University of Lille, France
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Abdelfattah El Ouaamari
Abdelfattah El Ouaamari
Robert Wood Johnson Medical School, USA
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Hardback ISBN:
978-1-83916-470-5
PDF ISBN:
978-1-83916-549-8
EPUB ISBN:
978-1-83916-550-4
Special Collection:
2022 ebook collection
No. of Pages:
358
Publication date:
19 Sep 2022
Book Chapter
Chapter 1: Chemical Approaches for Beta-cell Biology
By
Amedeo Vetere
;
Amedeo Vetere
Broad Institute, Chemical Biology & Therapeutics Science Program
415 Main Street
Cambridge
MA 02142
USA
[email protected]
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Vishal S. Parekh
;
Vishal S. Parekh
Broad Institute, Chemical Biology & Therapeutics Science Program
415 Main Street
Cambridge
MA 02142
USA
[email protected]
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Ashley E. Modell
;
Ashley E. Modell
Broad Institute, Chemical Biology & Therapeutics Science Program
415 Main Street
Cambridge
MA 02142
USA
[email protected]Department of Medicine, Harvard Medical School
Boston
MA 02115
USA
Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital
Boston
MA 02115
USA
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Veronika M. Shoba
;
Veronika M. Shoba
Broad Institute, Chemical Biology & Therapeutics Science Program
415 Main Street
Cambridge
MA 02142
USA
[email protected]
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Amit Choudhary
;
Amit Choudhary
Broad Institute, Chemical Biology & Therapeutics Science Program
415 Main Street
Cambridge
MA 02142
USA
[email protected]Department of Medicine, Harvard Medical School
Boston
MA 02115
USA
Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital
Boston
MA 02115
USA
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Bridget K. Wagner
Bridget K. Wagner
Broad Institute, Chemical Biology & Therapeutics Science Program
415 Main Street
Cambridge
MA 02142
USA
[email protected]
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Published:19 Sep 2022
-
Special Collection: 2022 ebook collection
Page range:
1 - 52
Citation
A. Vetere, V. S. Parekh, A. E. Modell, V. M. Shoba, A. Choudhary, and B. K. Wagner, in Nanotechnology for Diabetes Management, ed. A. Abderrahmani, S. Szunerits, R. Boukerroub, and A. El Ouaamari, The Royal Society of Chemistry, 2022, ch. 1, pp. 1-52.
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There is good evidence that targeting the beta cell could be an important component to developing the future of diabetes therapeutics. In this chapter, the authors review the principles of chemical biology that enable small-molecule discovery, the current state of the art for therapeutic approaches, novel beta cell-focused approaches to use small molecules that improve phenotypes, and more recent efforts to deliver therapeutics selectively to the beta cell.
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