This chapter reviews chemo- and pH-responsive polymer systems based on cyclodextrins, which show promise for pharmaceutical and biomedical applications. The categories and mechanism of cyclodextrin-based stimuli-responsive polymer systems are briefly overviewed in Sections 9.2 and 9.3. Chemical and pH stimuli for cyclodextrin-based stimuli-responsive polymer systems are briefly dealt with in the Section 9.4. Section 9.5 describes a few examples of cyclodextrin-based chemo- and pH-responsive polymer systems for pharmaceutical and biomedical applications. Section 9.5 has been fully updated, including highly interesting systems, for example, redox- and pH-responsive controlled release for anticancer drugs, hydrogels, and self-healing materials.