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Nucleic Acids in Chemistry and Biology
Edited by
G Michael Blackburn;
G Michael Blackburn
University of Sheffield, UK
Search for other works by this author on:
Michael J Gait;
Michael J Gait
MRC Laboratory of Molecular Biology (LMB), UK
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Jonathan K Watts
Jonathan K Watts
University of Massachusetts, USA
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Hardback ISBN:
978-1-78801-904-0
EPUB ISBN:
978-1-83916-324-1
PDF ISBN:
978-1-83767-132-8
Product Type:
Textbooks
Publication date:
24 Jun 2022
About this book
The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.
Nucleic Acids in Chemistry and Biology, The Royal Society of Chemistry, 2022.
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Nucleic Acids in Chemistry and Biology
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Table of contents
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Introduction and Overview†p1-19ByG. Michael Blackburn;G. Michael BlackburnKrebs Institute, School of Biosciences, University of SheffieldSheffield S10 2TNUKSearch for other works by this author on:Martin Egli;Martin EgliDepartment of Biochemistry, Vanderbilt University, School of MedicineNashvilleTennessee 37232-0146USA[email protected]Search for other works by this author on:Michael J. Gait;Michael J. GaitMRC Laboratory of Molecular Biology, Cambridge Biomedical CampusFrancis Crick AvenueCambridge CB2 0QHUKSearch for other works by this author on:Jonathan K. WattsJonathan K. WattsRNA Therapeutics Institute, University of Massachusetts Medical SchoolWorcesterMA01609USA[email protected]Search for other works by this author on:
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CHAPTER 2: DNA and RNA Structure†p20-95ByMartin EgliMartin EgliDepartment of Biochemistry, Vanderbilt University, School of MedicineNashvilleTennessee 37232-0146USA[email protected]Search for other works by this author on:
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CHAPTER 3: Nucleosides and Nucleotides†p96-169ByDavid M. Williams;David M. WilliamsKrebs Institute, School of Biosciences, University of SheffieldWestern BankS10 2TNUK[email protected]Search for other works by this author on:G. Michael BlackburnG. Michael BlackburnKrebs Institute, School of Biosciences, University of SheffieldWestern BankS10 2TNUK[email protected]Search for other works by this author on:
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CHAPTER 4: Genes and Genomes†p170-223ByNicholas RhindNicholas RhindDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical SchoolWorcesterMA01605USA[email protected]Search for other works by this author on:
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CHAPTER 5: RNA Transcription, Processing, Modification and Translation†p224-258ByJoerg E. BraunJoerg E. BraunSearch for other works by this author on:
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CHAPTER 6: Noncoding RNA†p259-278ByScott T. YoungerScott T. YoungerSearch for other works by this author on:
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CHAPTER 7: Synthesis of Nucleic Acids†p279-323ByJonathan K. Watts;Jonathan K. WattsRNA Therapeutics Institute, University of Massachusetts Medical SchoolWorcesterMA01605USA[email protected]Search for other works by this author on:Michael J. GaitMichael J. GaitMRC Laboratory of Molecular BiologyCambridgeCB2 0QHUKSearch for other works by this author on:
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CHAPTER 8: DNA and RNA Sequencing†p324-349ByMichael J. BoothMichael J. BoothSearch for other works by this author on:
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CHAPTER 9: Nucleic Acid Therapeutics†p350-402ByJonathan K. WattsJonathan K. WattsRNA Therapeutics Institute, University of Massachusetts Medical SchoolWorcesterMA01605USA[email protected]Search for other works by this author on:
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CHAPTER 10: In Vitro Evolution and Aptamers†p403-420ByGünter Mayer;Günter MayerLife and Medical Sciences Institute, Chair of Chemical Biology & Chemical Genetics, Center of Aptamer Research and Development, University of BonnBonnGermany[email protected]Search for other works by this author on:Paloma H. GiangrandePaloma H. GiangrandeSearch for other works by this author on:
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CHAPTER 11: Covalent Modifications of Nucleic Acids and Their Repair†p421-476ByG. Michael BlackburnG. Michael BlackburnSearch for other works by this author on:
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CHAPTER 12: Reversible Small Molecule–Nucleic Acid Interactions†p477-521ByW. David Wilson;W. David WilsonDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State UniversityAtlantaGA 30303USA[email protected]Search for other works by this author on:Ananya PaulAnanya PaulDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State UniversityAtlantaGA 30303USA[email protected]Search for other works by this author on:
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CHAPTER 13: Protein–DNA Interactions†p522-571ByBen Luisi;Ben LuisiDepartment of Biochemistry, University of CambridgeTennis Court RoadCambridgeCB2 1GAUK[email protected]Search for other works by this author on:Elliott StollarElliott StollarSchool of Life Sciences, University of LiverpoolLiverpoolL69 7ZBUKSearch for other works by this author on:
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CHAPTER 14: RNA–Protein Interactions†p572-626ByMichael E. HarrisMichael E. HarrisSearch for other works by this author on:
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CHAPTER 15: Online Content: Physical and Structural Techniques Applied to Nucleic AcidspE1-E50ByYitzhak Tor;Yitzhak TorDepartment of Chemistry and Biochemistry, University of CaliforniaSan DiegoLa JollaCA92093USASearch for other works by this author on:Kalle Gehring;Kalle GehringDepartment of Biochemistry, McGill UniversityMontrealQCH3G 0BCanadaSearch for other works by this author on:Daniele Fabris;Daniele FabrisDepartment of Chemistry, University of ConnecticutStorrsCT06269USASearch for other works by this author on:Martin Egli;Martin EgliDepartment of Biochemistry, Vanderbilt University, School of MedicineNashvilleTN37232USA[email protected]Search for other works by this author on:Andrei A. Korostelev;Andrei A. KorostelevRNA Therapeutics Institute, University of Massachusetts Medical SchoolWorcesterMA01605USASearch for other works by this author on:Timothy D. Craggs;Timothy D. CraggsDepartment of Chemistry, University of SheffieldSheffieldS3 7HFUKSearch for other works by this author on:Alice Pyne;Alice PyneDepartment of Chemistry, University of SheffieldSheffieldS3 7HFUKSearch for other works by this author on:Keith T. Gagnon;Keith T. GagnonDepartment of Biochemistry and Molecular Biology, School of Medicine, Southern Illinois UniversityCarbondaleIL62901USASearch for other works by this author on:Jonathan K. Watts;Jonathan K. WattsRNA Therapeutics Institute, University of Massachusetts Medical SchoolWorcesterMA01605USASearch for other works by this author on:Thomas E. Cheatham III;Thomas E. Cheatham IIIDepartment of Medicinal Chemistry, University of Utah, College of PharmacySalt Lake CityUT84112USASearch for other works by this author on:Nigel G. J. RichardsNigel G. J. RichardsSchool of Chemistry, Cardiff UniversityPark PlaceCardiffCF10 3ATUKSearch for other works by this author on:
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Glossaryp627-647ByG. M. Blackburn;G. M. BlackburnUniversity of SheffieldUKSearch for other works by this author on:M. J. Gait;M. J. GaitMRC Laboratory of Molecular Biology (LMB)UKSearch for other works by this author on:N. Rhind;N. RhindUniversity of Massachusetts Medical SchoolUSASearch for other works by this author on:J. K. WattsJ. K. WattsUniversity of Massachusetts Medical SchoolUSASearch for other works by this author on:
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