Nucleic Acids in Chemistry and Biology
CHAPTER 3: Nucleosides and Nucleotides†
Published:24 Jun 2022
David M. Williams, G. Michael Blackburn, 2022. "Nucleosides and Nucleotides†", Nucleic Acids in Chemistry and Biology, G Michael Blackburn, Martin Egli, Michael J Gait, Jonathan K Watts
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In this chapter we describe methods for the chemical synthesis of modified nucleosides and nucleotides. Because most naturally nucleosides and nucleotides are commercially available, syntheses have been directed at the generation of nucleosides containing modified bases and sugars and nucleotides in which oxygen atoms in the phosphate ester are replaced by other heteroatoms. The enzymatic processes associated with nucleotide metabolism are described and the roles of nucleotides in biology are discussed. Finally, the biological properties of nucleosides as antiviral and anticancer agents are highlighted.