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This chapter offers a brief overview of the integration of medical instruments and sensors with artificial intelligence (AI) for advanced clinical decision support systems, which could help decision makers and healthcare systems to improve in the approach to information, insights and surrounding contexts of health, as well as to promote the uptake of personalized medicine. Relying on these systems, volatile organic compound (VOC) sensing devices could enable interactive and evolving clinical decisions for use in evidence-based analysis and recommendations as well as for personalized monitoring of disease progress and treatment. The ongoing challenges and future opportunities associated with VOC-enabled medical sensors in clinical decisions are presented and discussed.

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