NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces
NMR spectroscopy has found a wide range of applications in life sciences over recent decades. Providing a comprehensive amalgamation of the scattered knowledge of how to apply high-resolution NMR techniques to biomolecular systems, this book will break down the conventional stereotypes in the use of NMR for structural studies. The major focus is on novel approaches in NMR which deal with the functional interface of either protein-protein interactions or protein-lipid interactions. Bridging the gaps between structural and functional studies, the Editors believe a thorough compilation of these studies will open an entirely new dimension of understanding of crucial functional motifs. This in turn will be helpful for future applications into drug design or better understanding of systems.
The book will appeal to NMR practitioners in industry and academia who are looking for a comprehensive understanding of the possibilities of applying high-resolution NMR spectroscopic techniques in probing biomolecular interactions.
NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces, The Royal Society of Chemistry, 2022.
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Chapter 1: Theory and Applications of NMR Spectroscopy in Biomolecular Structures and Dynamics of Proteinsp1-28ByKousik Chandra;Kousik ChandraKing Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences & Engineering Division (BESE)Thuwal23955-6900Saudi Arabia[email protected]Search for other works by this author on:Abdul Hamid Emwas;Abdul Hamid EmwasKing Abdullah University of Science and Technology. Core LabsThuwal 23955-6900Kingdom of Saudi ArabiaSearch for other works by this author on:Samah Al-Harthi;Samah Al-HarthiKing Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences & Engineering Division (BESE)Thuwal23955-6900Saudi Arabia[email protected]Search for other works by this author on:Zeyad Al-Talla;Zeyad Al-TallaKing Abdullah University of Science and Technology (KAUST), Ali I. Al-Naimi Petroleum Engineering Research Center (ANPERC)Thuwal23955-6900Saudi ArabiaSearch for other works by this author on:Dina Hajjar;Dina HajjarUniversity of Jeddah, College of Science, Department of BiochemistryJeddahSaudi ArabiaSearch for other works by this author on:Arwa Abdulaziz Makki;Arwa Abdulaziz MakkiUniversity of Jeddah, College of Science, Department of BiochemistryJeddahSaudi ArabiaSearch for other works by this author on:Ghada Khouqeer;Ghada KhouqeerImam Mohammad Ibn Saud Islamic University (IMSIU)RiyadhKingdom of Saudi ArabiaSearch for other works by this author on:Mariusz JaremkoMariusz JaremkoKing Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences & Engineering Division (BESE)Thuwal23955-6900Saudi Arabia[email protected]Search for other works by this author on:
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Chapter 2: Multistate Structures and Dynamics at Atomic Resolution Using Exact Nuclear Overhauser Enhancements (eNOEs)p29-55ByRoland RiekRoland RiekSearch for other works by this author on:
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Chapter 3: Protein Backbone and Side-chain 15N Spin Relaxation Techniques to Study Biomacromolecular Interactionsp56-81ByV. Kharchenko;V. KharchenkoDivision of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST)Thuwal23955-6900Saudi Arabia[email protected]Search for other works by this author on:A. Ejchart;A. EjchartInstitute of Biochemistry and Biophysics, Polish Academy of SciencesPawinskiego 5A02-106WarsawPolandSearch for other works by this author on:L. JaremkoL. JaremkoDivision of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST)Thuwal23955-6900Saudi Arabia[email protected]Search for other works by this author on:
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Chapter 4: Lineshape Analysis as a Tool for Probing Functional Motions at Biological Interfacesp82-121BySoumya De;Soumya DeSchool of Bioscience, Indian Institute of Technology KharagpurKharagpurWest Bengal 721302IndiaSearch for other works by this author on:Alexander I. Greenwood;Alexander I. GreenwoodUniversity of Cincinnati, A&S-Chemistry301 Clifton St.CincinnatiOH 45221-0172USASearch for other works by this author on:L. Andrea Acevedo;L. Andrea AcevedoGlaxoSmithKline, Protein, Cellular, and Structure Sciences Group1250 S Collegeville RdCollegevillePA 19426USASearch for other works by this author on:Nathan E. Korson;Nathan E. KorsonCornell University, Department of Molecular Biology & Genetics526 Campus RdIthacaNY 14853USA[email protected]Search for other works by this author on:Linda K. NicholsonLinda K. NicholsonCornell University, Department of Molecular Biology & Genetics526 Campus RdIthacaNY 14853USA[email protected]Search for other works by this author on:
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Chapter 5: Monitoring Interfaces of Thermo- and pH-responsive Polymers Using Solvent Relaxationp122-141ByIpsita Chakraborty;Ipsita ChakrabortyDepartment of Biophysics, Bose InstituteP-1/12 C.I.T. Scheme VII-MKolkata700054IndiaSearch for other works by this author on:Rangeet BhattacharyyaRangeet BhattacharyyaDepartment of Physical Sciences, Indian Institute of Science Education and Research KolkataMohanpur741246,WBIndia[email protected]Search for other works by this author on:
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Chapter 6: NMR-based Ligand–Receptor Interaction Studies under Conventional and Unconventional Conditionsp142-178ByC. Ciaramelli;C. CiaramelliBioOrgNMR Lab, Department of Biotechnology and Biosciences, University of Milano-BicoccaPiazza della Scienza 220126MilanItaly[email protected]Search for other works by this author on:A. Palmioli;A. PalmioliBioOrgNMR Lab, Department of Biotechnology and Biosciences, University of Milano-BicoccaPiazza della Scienza 220126MilanItaly[email protected]Search for other works by this author on:C. AiroldiC. AiroldiBioOrgNMR Lab, Department of Biotechnology and Biosciences, University of Milano-BicoccaPiazza della Scienza 220126MilanItaly[email protected]Search for other works by this author on:
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Chapter 7: Multi-frequency Saturation Transfer Difference NMR to Characterize Weak Protein–Ligand Complexesp179-202BySerena Monaco;Serena MonacoSchool of Pharmacy, University of East AngliaNorwich Research ParkNR4 7TJNorwichUKSearch for other works by this author on:Jesús AnguloJesús AnguloSchool of Pharmacy, University of East AngliaNorwich Research ParkNR4 7TJNorwichUKDepartment of Organic Chemistry, Faculty of Chemistry, University of Seville41012 SevilleSpain[email protected]Instituto de Investigaciones Químicas (CSIC-US)Avda. Américo Vespucio49. 41092 SevillaSpain[email protected]Search for other works by this author on:
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Chapter 8: Structural Insight into the Slowly Exchanging Dark States at the Functional Interaction Interfacep203-235ByDipita Bhattacharyya;Dipita BhattacharyyaDepartment of Biophysics, Bose Institute700054 KolkataIndia[email protected][email protected][email protected]Search for other works by this author on:Janarthanan Krishnamoorthy;Janarthanan KrishnamoorthyDepartment of Biomedical Engineering, Jimma Institute of Technology, Jimma UniversityJimmaEthiopiaSearch for other works by this author on:Anirban BhuniaAnirban BhuniaDepartment of Biophysics, Bose Institute700054 KolkataIndia[email protected][email protected][email protected]Search for other works by this author on:
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Chapter 9: Dynamics of Protein–Nanoparticle Interactions Using NMRp236-253ByVarsha Brahmkhatri;Varsha BrahmkhatriCentre for Nano and Material Sciences, Jain UniversityJain Global CampusBengaluru562112KarnatakaIndia[email protected]Search for other works by this author on:Hanudatta S. AtreyaHanudatta S. AtreyaCentre for Nano and Material Sciences, Jain UniversityJain Global CampusBengaluru562112KarnatakaIndia[email protected]Search for other works by this author on:
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Chapter 10: NMR Structures, Dynamics and Interactions of Protein Complexes in β2 Integrinsp254-276BySurajit BhattacharjyaSurajit BhattacharjyaSchool of Biological Sciences, Nanyang Technological University60 Nanyang DriveSingapore 637551Singapore[email protected]Search for other works by this author on:
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Chapter 11: Describing Dynamic Chaperone–Client Complexes by Solution NMR Spectroscopyp277-302ByS. Hiller;S. HillerBiozentrum, University of BaselKlingelbergstrasse 704056 BaselSwitzerland[email protected][email protected]Search for other works by this author on:B. M. BurmannB. M. BurmannWallenberg Centre for Molecular and Translational Medicine, University of GothenburgGothenburg40530SwedenDepartment of Chemistry and Molecular Biology, University of GothenburgGothenburg40530SwedenSearch for other works by this author on:
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Chapter 12: Methyl-TROSY NMR Spectroscopy in the Investigation of Allosteric Cooperativity in Large Biomolecular Complexesp303-345ByRui HuangRui HuangUniversity of Guelph, Department of Chemistry482 Gordon StreetGuelphONN1G 1Y4Canada[email protected]Search for other works by this author on:
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Chapter 13: Characterizing Conformational Diversity of G Protein-coupled Receptors by Solution NMR Spectroscopyp346-382ByFeng-Jie Wu;Feng-Jie WuDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]The Florey Institute of Neuroscience and Mental Health, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:Fabian Bumbak;Fabian BumbakDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]The Florey Institute of Neuroscience and Mental Health, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:Mohammad Hossein Tanipour;Mohammad Hossein TanipourDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]The Florey Institute of Neuroscience and Mental Health, University of MelbourneParkville3052VICAustraliaBio21 Institute of Molecular Sciences and Biotechnology, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:Kazem Asadollahi;Kazem AsadollahiDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]The Florey Institute of Neuroscience and Mental Health, University of MelbourneParkville3052VICAustraliaBio21 Institute of Molecular Sciences and Biotechnology, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:Tasneem M. Vaid;Tasneem M. VaidDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]The Florey Institute of Neuroscience and Mental Health, University of MelbourneParkville3052VICAustraliaBio21 Institute of Molecular Sciences and Biotechnology, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:Ashish Sethi;Ashish SethiDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]Bio21 Institute of Molecular Sciences and Biotechnology, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:Daniel J. Scott;Daniel J. ScottDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]The Florey Institute of Neuroscience and Mental Health, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:Paul R. GooleyPaul R. GooleyDepartment of Biochemistry and Pharmacology, University of MelbourneParkville3052VICAustralia[email protected]Bio21 Institute of Molecular Sciences and Biotechnology, University of MelbourneParkville3052VICAustraliaSearch for other works by this author on:
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Chapter 14: Characterising Intrinsically Disordered Proteins Using NMR Spectroscopy and MD Simulationsp383-410ByG. T. Heller;G. T. HellerDepartment of Structural and Molecular Biology, Division of Biosciences, University College LondonLondonWC1E 6BTUK[email protected]Search for other works by this author on:L. Yu;L. YuDepartment of Structural and Molecular Biology, Division of Biosciences, University College LondonLondonWC1E 6BTUK[email protected]Search for other works by this author on:D. F. HansenD. F. HansenDepartment of Structural and Molecular Biology, Division of Biosciences, University College LondonLondonWC1E 6BTUK[email protected]Search for other works by this author on:
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Chapter 15: Structure- and Dynamics-guided Drug Development Using NMR and its Application to Diverse Pharmaceutical Modalitiesp411-448ByKoh TakeuchiKoh TakeuchiGraduate School of Pharmaceutical Sciences, The University of Tokyo7-3-1 HongoBunkyoTokyo 113-0033[email protected]Search for other works by this author on:
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Chapter 16: Locating Hydrogen Atoms Using Fast-MAS Solid-state NMR and microEDp449-495ByYusuke NishiyamaYusuke NishiyamaRIKEN-JEOL Collaboration CenterYokohamaKanagawa 230-0045JapanSearch for other works by this author on:
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Chapter 17: Membranes, Minerals and Magnets: Application of NMR Spectroscopy to Biological Interfacesp496-529ByJ. E. Kent;J. E. KentSanford Burnham Prebys Medical Discovery Institute10901 North Torrey Pines RoadLa JollaCA 92037USA[email protected]Search for other works by this author on:K. Shin;K. ShinSanford Burnham Prebys Medical Discovery Institute10901 North Torrey Pines RoadLa JollaCA 92037USA[email protected]Search for other works by this author on:F. M. MarassiF. M. MarassiSanford Burnham Prebys Medical Discovery Institute10901 North Torrey Pines RoadLa JollaCA 92037USA[email protected]Search for other works by this author on:
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Chapter 18: Solid-state NMR Shows That the Structure and Dynamics of Specific Residues in the Membrane Receptor CXCR1 Are Altered by Interactions with Specific Residues in Its Agonist IL-8p530-562ByR. K. Rai;R. K. RaiIndiana University School of MedicineIndianapolisIN 46202-3082USASearch for other works by this author on:A. A. De Angelis;A. A. De AngelisDepartment of Chemistry and Biochemistry, University of CaliforniaSan Diego, La JollaCA 92093USA[email protected]Search for other works by this author on:S. H. Park;S. H. ParkDepartment of Chemistry and Biochemistry, University of CaliforniaSan Diego, La JollaCA 92093USA[email protected]Search for other works by this author on:S. Berkamp;S. BerkampErnst Ruska-Centre for Microscopy and Spectroscopy with ElectronsER-C-352425 JülichGermanySearch for other works by this author on:S. J. OpellaS. J. OpellaDepartment of Chemistry and Biochemistry, University of CaliforniaSan Diego, La JollaCA 92093USA[email protected]Search for other works by this author on:
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Chapter 19: High-resolution NMR Studies of Antibiotics in Membranesp563-582ByMaik Derks;Maik DerksNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityPadualaan 83584 CH UtrechtThe Netherlands[email protected]Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht UniversityPadualaan 83584 CH UtrechtThe NetherlandsSearch for other works by this author on:Leanna Smid;Leanna SmidNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityPadualaan 83584 CH UtrechtThe Netherlands[email protected]Search for other works by this author on:Raj Kumar;Raj KumarNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityPadualaan 83584 CH UtrechtThe Netherlands[email protected]Search for other works by this author on:Lea Marie Becker;Lea Marie BeckerNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityPadualaan 83584 CH UtrechtThe Netherlands[email protected]Search for other works by this author on:Rhythm Shukla;Rhythm ShuklaNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityPadualaan 83584 CH UtrechtThe Netherlands[email protected]Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht UniversityPadualaan 83584 CH UtrechtThe NetherlandsSearch for other works by this author on:Eefjan Breukink;Eefjan BreukinkMembrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht UniversityPadualaan 83584 CH UtrechtThe NetherlandsSearch for other works by this author on:Markus WeingarthMarkus WeingarthNMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityPadualaan 83584 CH UtrechtThe Netherlands[email protected]Search for other works by this author on:
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Chapter 20: New Concepts for the Mechanisms of Action of Antimicrobial Peptides from Solid-state NMR Investigationsp583-613ByE. S. Salnikov;E. S. SalnikovUniversity of Strasbourg/CNRS, UMR7177, Institut de Chimie de Strasbourg67070 StrasbourgFrance[email protected]Search for other works by this author on:E. Glattard;E. GlattardUniversity of Strasbourg/CNRS, UMR7177, Institut de Chimie de Strasbourg67070 StrasbourgFrance[email protected]Search for other works by this author on:M. Lointier;M. LointierUniversity of Strasbourg/CNRS, UMR7177, Institut de Chimie de Strasbourg67070 StrasbourgFrance[email protected]Search for other works by this author on:J. Raya;J. RayaUniversity of Strasbourg/CNRS, UMR7177, Institut de Chimie de Strasbourg67070 StrasbourgFrance[email protected]Search for other works by this author on:D. W. Juhl;D. W. JuhlUniversity of Strasbourg/CNRS, UMR7177, Institut de Chimie de Strasbourg67070 StrasbourgFrance[email protected]Search for other works by this author on:A. Saad;A. SaadUniversity of Strasbourg/CNRS, UMR7177, Institut de Chimie de Strasbourg67070 StrasbourgFrance[email protected]Search for other works by this author on:B. BechingerB. BechingerUniversity of Strasbourg/CNRS, UMR7177, Institut de Chimie de Strasbourg67070 StrasbourgFrance[email protected]Institut Universitaire de France (IUF)ParisFranceSearch for other works by this author on:
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Chapter 21: Structure and Dynamics of Native Biological Materials by Solid-state NMR Spectroscopyp614-655ByRicha Dubey;Richa DubeyCentre of Biomedical Magnetic ResonanceSGPGIMS Campus, Raibarelly RoadLucknow 226014India[email protected]Search for other works by this author on:Neeraj SinhaNeeraj SinhaCentre of Biomedical Magnetic ResonanceSGPGIMS Campus, Raibarelly RoadLucknow 226014India[email protected]Search for other works by this author on:
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Chapter 22: The Lipid Phase of the Stratum Corneum Studied by Solid-state NMR: A Not So Rigid Barrierp656-680ByOskar Engberg;Oskar EngbergInstitute of Medical Physics and Biophysics, University of LeipzigHärtelstr. 16-18D-04107 LeipzigGermany[email protected]Search for other works by this author on:Daniel HusterDaniel HusterInstitute of Medical Physics and Biophysics, University of LeipzigHärtelstr. 16-18D-04107 LeipzigGermany[email protected]Search for other works by this author on:
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