High-resolution NMR Studies of Antibiotics in Membranes

Derks, Maik; Smid, Leanna; Kumar, Raj; Becker, Lea Marie; Shukla, Rhythm; Breukink, Eefjan; Weingarth, Markus

doi:10.1039/9781839165702-00563

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New Developments in NMR

NMR Spectroscopy for Probing Functional Dynamics at Biological Interfaces

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DOI:

https://doi.org/10.1039/9781839165702

Hardback ISBN:

978-1-83916-209-1

PDF ISBN:

978-1-83916-570-2

EPUB ISBN:

978-1-83916-571-9

Special Collection: 2022 ebook collection

Series: New Developments in NMR

No. of Pages:

708

Publication date:

17 Aug 2022

Book Chapter

Chapter 19: High-resolution NMR Studies of Antibiotics in Membranes

Maik Derks

NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

[email protected]

Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

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Leanna Smid

NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

[email protected]

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Raj Kumar

NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

[email protected]

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Lea Marie Becker

NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

[email protected]

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Rhythm Shukla

NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

[email protected]

Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

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Eefjan Breukink

Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

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Markus Weingarth

NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University

Padualaan 8

3584 CH Utrecht

The Netherlands

[email protected]

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Doi:

https://doi.org/10.1039/9781839165702-00563

Published:

17 Aug 2022
Special Collection: 2022 ebook collection

Series: New Developments in NMR

Page range:

563 - 582

The rapid rise of antimicrobial resistance calls for the development of new antibiotics. Ideal templates for next-generation antibiotics could be drugs that target the cell wall precursor, Lipid II, with vancomycin, nisin, or teixobactin being well-known examples. In this chapter the authors review a selection of NMR studies on the mode of action of Lipid II-binding antibiotics with an emphasis on solid-state NMR findings in lipid membranes that are vital to obtain physiologically relevant drug-binding modes.

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