Biomaterial Based Approaches to Study the Tumour Microenvironment
The tumour microenvironment is increasingly recognized as an important contributor to cancer progression and treatment. However, most cancer studies continue to be performed in 2D tissue culture dishes that do not capture the characteristics of the tumour niche. This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies, including scaffold design and synthesis, chemical signalling and delivery, and co-culture, microfluidics, and organ-on-a-chip tools that can be used to mimic tumour microenvironment features. This book also includes discussion of emerging imaging methods compatible with tumour microenvironment mimicking biomaterials and discusses applications of such models in immuno-oncology, metastasis, and drug screening.
Edited by two leaders in the field, this book will appeal to graduate students and researchers working in biomaterials science, chemical and biomedical engineering departments.
Biomaterial Based Approaches to Study the Tumour Microenvironment, The Royal Society of Chemistry, 2022.
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Table of contents
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Chapter 1: Tissue Engineering Models for Cancer Pathologyp1-10ByJessica O. Winter;Jessica O. WinterWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State UniversityColumbusOHUSA[email protected]Department of Biomedical Engineering, The Ohio State UniversityColumbusOHUSASearch for other works by this author on:Shreyas S. RaoShreyas S. RaoDepartment of Chemical and Biological Engineering, The University of AlabamaTuscaloosaALUSA[email protected]Search for other works by this author on:
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Chapter 2: Introduction to the Tumor Microenvironmentp11-29ByIsaac P. Witz;Isaac P. WitzThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Science, Tel Aviv UniversityTel AvivIsrael[email protected]Search for other works by this author on:Sivan IzraelySivan IzraelyThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Science, Tel Aviv UniversityTel AvivIsrael[email protected]Search for other works by this author on:
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Chapter 3: Mimicking Fibrous Topographical Features of the Tumor Microenvironmentp30-59ByS. Sharma;S. SharmaDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State UniversityBlacksburgVirginia24061USA[email protected]Search for other works by this author on:A. S. NainA. S. NainDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State UniversityBlacksburgVirginia24061USA[email protected]Search for other works by this author on:
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Chapter 4: Mimicking Mechanical Features of the Tumor Microenvironmentp60-96ByC. T. MierkeC. T. MierkeLeipzig University, Faculty of Physics and Earth Science, Biological Physics DivisionLinnestr. 504103 LeipzigGermany[email protected]Search for other works by this author on:
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Chapter 5: Mimicking Chemical Features of the Tumor Microenvironmentp97-140BySruthi Rayadurgam Jayaprakash;Sruthi Rayadurgam JayaprakashDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology MadrasChennai 600036India[email protected]Search for other works by this author on:Indira Priyadarshani Patra;Indira Priyadarshani PatraDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology MadrasChennai 600036India[email protected]Search for other works by this author on:Sushmita Bist;Sushmita BistDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology MadrasChennai 600036India[email protected]Search for other works by this author on:Shantanu PradhanShantanu PradhanDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology MadrasChennai 600036India[email protected]Search for other works by this author on:
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Chapter 6: Mimicking Multicellular Features of the Tumor Microenvironmentp141-162ByRodrigo Curvello;Rodrigo CurvelloDepartment of Chemical & Biological Engineering, Faculty of Engineering, Monash UniversityMelbourneVIC 3800Australia[email protected]Search for other works by this author on:Daniela LoessnerDaniela LoessnerDepartment of Chemical & Biological Engineering, Faculty of Engineering, Monash UniversityMelbourneVIC 3800Australia[email protected]Department of Materials Science and Engineering, Faculty of Engineering, Monash UniversityMelbourneVIC 3800AustraliaDepartment of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash UniversityMelbourneVIC 3800AustraliaLeibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe StraβeDresdenGermanySearch for other works by this author on:
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Chapter 7: Cell Patterning to Mimic Tumor Anatomyp163-196ByMolly C. Brennan;Molly C. BrennanDepartment of Chemical and Biological Engineering, Princeton University303 Hoyt Laboratory, William StreetPrincetonNJ 08544USA[email protected]Search for other works by this author on:Celeste M. NelsonCeleste M. NelsonDepartment of Chemical and Biological Engineering, Princeton University303 Hoyt Laboratory, William StreetPrincetonNJ 08544USA[email protected]Department of Molecular Biology, Princeton University303 Hoyt Laboratory, William StreetPrincetonNJ 08544USASearch for other works by this author on:
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Chapter 8: Advanced Scaffold Design via Electrospinningp197-225ByYili Zhao;Yili ZhaoCollege of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech UniversityHangzhou 310018People's Republic of China[email protected]Search for other works by this author on:Jie XiongJie XiongCollege of Textile Science and Engineering (International Institute of Silk), Zhejiang Sci-Tech UniversityHangzhou 310018People's Republic of China[email protected]Search for other works by this author on:
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Chapter 9: Advanced Scaffold Fabrication using Additive Manufacturingp226-251ByTaylor E. Scott;Taylor E. ScottDepartment of Chemical and Biomolecular Engineering, Vanderbilt UniversityNashvilleTN, USA[email protected]Search for other works by this author on:Scott A. GuelcherScott A. GuelcherDepartment of Chemical and Biomolecular Engineering, Vanderbilt UniversityNashvilleTN, USA[email protected]Search for other works by this author on:
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Chapter 10: Microfluidic Models of the Tumor Microenvironmentp252-278ByChia-Wen Chang;Chia-Wen ChangDepartment of Chemical and Biomolecular Engineering, The Ohio State UniversityColumbusOHUSASearch for other works by this author on:Jacob C. Holter;Jacob C. HolterDepartment of Biomedical Engineering, The Ohio State UniversityColumbusOHUSASearch for other works by this author on:Jonathan W. SongJonathan W. SongDepartment of Mechanical and Aerospace Engineering, The Ohio State UniversityColumbusOHUSA[email protected]The Comprehensive Cancer Center, The Ohio State UniversityColumbusOHUSASearch for other works by this author on:
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Chapter 11: Modeling of the Tumor Microenvironment in Tumor Organoidsp279-303ByEthan Shelkey;Ethan ShelkeyWake Forest Institute for Regenerative Medicine, Wake Forest School of MedicineWinston-SalemNCUSA[email protected]Search for other works by this author on:Anthony Dominijanni;Anthony DominijanniWake Forest Institute for Regenerative Medicine, Wake Forest School of MedicineWinston-SalemNCUSA[email protected]Search for other works by this author on:Steven Forsythe;Steven ForsytheWake Forest Institute for Regenerative Medicine, Wake Forest School of MedicineWinston-SalemNCUSA[email protected]Search for other works by this author on:David Oommen;David OommenWake Forest Institute for Regenerative Medicine, Wake Forest School of MedicineWinston-SalemNCUSA[email protected]Search for other works by this author on:Shay SokerShay SokerWake Forest Institute for Regenerative Medicine, Wake Forest School of MedicineWinston-SalemNCUSA[email protected]Comprehensive Cancer Center at Wake Forest Baptist MedicalWinston-SalemNCUSASearch for other works by this author on:
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Chapter 12: Imaging in Scaffoldsp304-341ByJocelyn Martinez;Jocelyn MartinezDepartment of Biomedical Engineering, Texas A&M University3120 TAMUCollege StationTX 77843USA[email protected]Search for other works by this author on:Nianchao Wang;Nianchao WangDepartment of Biomedical Engineering, Texas A&M University3120 TAMUCollege StationTX 77843USA[email protected]Search for other works by this author on:Linghao Hu;Linghao HuDepartment of Biomedical Engineering, Texas A&M University3120 TAMUCollege StationTX 77843USA[email protected]Search for other works by this author on:Elizabeth Cardona Benitez;Elizabeth Cardona BenitezDepartment of Biomedical Engineering, Texas A&M University3120 TAMUCollege StationTX 77843USA[email protected]Search for other works by this author on:Uyen Nguyen;Uyen NguyenDepartment of Biomedical Engineering, Texas A&M University3120 TAMUCollege StationTX 77843USA[email protected]Search for other works by this author on:Ricardo Martinez;Ricardo MartinezDepartment of Biomedical Engineering, Texas A&M University3120 TAMUCollege StationTX 77843USA[email protected]Search for other works by this author on:Alex J. WalshAlex J. WalshDepartment of Biomedical Engineering, Texas A&M University3120 TAMUCollege StationTX 77843USA[email protected]Search for other works by this author on:
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Chapter 13: The Intersection of Biomaterials, Tissue Engineering, and Immuno-oncologyp342-383ByAbigail J. Clevenger;Abigail J. ClevengerDepartment of Biomedical Engineering, Texas A&M UniversityCollege Station, 3120 TAMU, College StationTX 77843USA[email protected]Search for other works by this author on:Sabrina N. VandenHeuvel;Sabrina N. VandenHeuvelDepartment of Biomedical Engineering, Texas A&M UniversityCollege Station, 3120 TAMU, College StationTX 77843USA[email protected]Search for other works by this author on:Shreya RaghavanShreya RaghavanDepartment of Biomedical Engineering, Texas A&M UniversityCollege Station, 3120 TAMU, College StationTX 77843USA[email protected]Department of Nanomedicine, Houston Methodist Research InstituteHoustonTXUSASearch for other works by this author on:
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Chapter 14: Tissue Engineered Models of Metastasis: Focus on Bone Metastasisp384-414ByN. Sempertegui;N. SemperteguiNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell UniversityIthacaNY 14853USA[email protected]Search for other works by this author on:C. FischbachC. FischbachNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell UniversityIthacaNY 14853USA[email protected]Kavli Institute at Cornell for Nanoscale Science, Cornell UniversityIthacaNY 14853USASearch for other works by this author on:
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Chapter 15: Tissue-engineered Cancer Models in Drug Screeningp415-449ByR. Cao;R. CaoInstitute of Biomedical Engineering, University of Toronto164 College StreetTorontoONM5S 3G9Canada[email protected]Search for other works by this author on:A. Fomina;A. FominaInstitute of Biomedical Engineering, University of Toronto164 College StreetTorontoONM5S 3G9Canada[email protected]Search for other works by this author on:A. P. McGuiganA. P. McGuiganInstitute of Biomedical Engineering, University of Toronto164 College StreetTorontoONM5S 3G9Canada[email protected]Department of Chemical Engineering and Applied Chemistry200 College StreetTorontoONM5R 3E5CanadaSearch for other works by this author on:
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