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This chapter focuses on the theoretical framework, applications, and assessment of systemic diagrams and systemic assessment questions, one of the tools that can be used to assess students' meaningful understanding in organic chemistry. The nature of organic chemistry and the points where learners have difficulties are discussed along with how meaningful understanding can be actualized in organic chemistry and how important it is to assess meaningful understanding in depth. Then, in the context of the systemic approach to teaching and learning (SATL), systemic diagrams and systemic assessment questions are examined. An assessment is then made in terms of research conducted in organic chemistry education. This section also provides a sample systemic assessment questions (SAQs) diagram for aromatic compounds that can be used by chemistry teachers and educators.

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