Photochemistry: Volume 50
Recent advances of visible-light-induced carbon–sulfur bond formation
Published:09 Dec 2022
Jiaxu Feng, Kui Lu, Xia Zhao, 2022. "Recent advances of visible-light-induced carbon–sulfur bond formation", Photochemistry: Volume 50, Stefano Crespi, Stefano Protti
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The sulfur-containing frameworks are widely existed in many natural products, pharmaceutical molecules, and organic functional materials owing to its biological activities and optical properties.1 Additionally, sulfur-containing intermediate plays important roles in total synthesis of natural products and diverse synthetic modifications.2 Based on the seminal studies have been reported by MacMillan, Stephenson, Yoon and other groups, visible-light-mediated photoredox has attracted much attention for the construction of complex organic building blocks because its inherent feature such as clean, environmentally-friendly, inexpensive, renewable and ease of handling.3 The classical strategies on the preparation of sulfur-containing compounds have some limitations, such as require strong base, strong oxidation, toxic transition-metal catalyst, harsh reaction conditions or expensive and not easily accessible substrates. Within recent decades, blooming progress of construction of C–S bond has been made using direct or indirect strategies through photocatalyst, photocatalyst-free or photocatalyst/transition-metal dual catalysis. Several excellent reviews have summarized the photochemical strategies for the synthesis of organosulphur compounds.4 This review will focus on the recent advances in visible-light-promoted C–S bond construction reported in the last three years through the formation of different sulfur-centered radicals. This manuscript mainly shows two kinds of sulfur-centered radicals including thiyl radicals and sulfonyl radicals, along with related radical substitution and addition reaction for the construction of structural diverse organosulfur molecules under mild conditions.