The design and synthesis of organochalcogen compounds (S, Se, Te) have attracted considerable attention from the scientific community due to their diverse applications in biological, chemical, and material science. Among the different strategies to access the C − Chalcogen bond, the use of electrophilic organochalcogen species is prominent. In this regard, the current chapter will highlight recent advances in the formation of C − Chalcogen bonds via electrophilic organochalcogen species. In addition, the use of bench stable electrophilic organochalcogen species as well as in situ generation and their uses are covered in this chapter.