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Chalcogen Chemistry: Fundamentals and Applications
Edited by
Vito Lippolis;
Vito Lippolis
Complesso Universitario di Monserrato, Italy
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Eder J. Lenardão;
Eder J. Lenardão
Universidade Federal de Pelota, Brazil
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Antonio L. Braga
Antonio L. Braga
Universidade Federal de Santa Catarina, Brazil
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Hardback ISBN:
978-1-83916-422-4
PDF ISBN:
978-1-83916-738-6
EPUB ISBN:
978-1-83916-739-3
Special Collection:
2023 ebook collection
No. of Pages:
728
Publication date:
15 Feb 2023
Book Chapter
Chapter 25: Small Organoselenium Catalysts as a Potential Manipulator for Redox Homeostasis and Proteostasis
By
Kenta Arai
Kenta Arai
Department of Chemistry, School of Science, Tokai University
Kitakaname
Hiratsuka-shi
Kanagawa 259-1292
Japan
k-arai4470@tokai-u.jp
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Published:15 Feb 2023
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Special Collection: 2023 ebook collection
Page range:
648 - 665
Citation
K. Arai, in Chalcogen Chemistry: Fundamentals and Applications, ed. V. Lippolis, C. Santi, E. J. Lenardão, and A. L. Braga, The Royal Society of Chemistry, 2023, ch. 25, pp. 648-665.
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Oxidative stress in the endoplasmic reticulum (ER) triggers the dysfunction of redox enzymes involved in protein quality control and ultimately misfolding diseases. In this chapter, we focus on small organoselenium catalysts of less than 1000 Da, which have been recently reported as antioxidant catalysts and protein folding regulators, and discuss their potential pharmacological applications in ER proteostasis.
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