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The use of molecularly imprinted polymers in sample preparation is nowadays well-established thanks to their ability to provide unprecedented selectivity during extraction and clean-up steps. However, both their synthesis and subsequent use are far from being considered green. Accordingly, in the present chapter, the greenness of the different steps and strategies for the preparation and use of molecularly imprinted polymers in sample preparation is critically reviewed, and recent alternatives to make the use of molecularly imprinted polymers more sustainable are provided.

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