Bioactive Delivery Systems for Lipophilic Nutraceuticals: Formulation, Fabrication, and Application
There is growing interest in the food, supplements, cosmetics, and pharmaceutical industries in improving the healthiness of their products by incorporating lipophilic bioactive substances like oil-soluble vitamins (A, D and E), omega-3 fatty acids, and nutraceuticals (carotenoids, curcuminoids and flavonoids). However, there are many challenges that need to be overcome due to their poor water-solubility, chemical stability, and bioavailability. For this reason, there is interest in the development of effective encapsulation technologies to increase the efficacy of lipophilic bioactives.
This book reviews the encapsulation systems currently available for delivering lipophilic bioactives, including their preparation, functionality, and application range, including nanoemulsions, emulsions, Pickering emulsions, HIPEs, microgels, organogels and liposomes. Chapters 1-2 review the biological activity of delivery systems and lipophilic bioactives. Chapters 3-5 describe the materials and preparation methods used to assemble delivery systems. Chapters 6-17 focus on the formation and application of different kinds of delivery systems. Chapter 18 discusses future trends in the development of bioactive delivery systems.
Edited and authored by world renowned scholars, the book provides a state-of-the-art overview of the design, fabrication, and utilization of delivery systems for bioactives that will be useful for academic, government, and industrial scientists in fields such as pharmaceuticals, cosmetics, agriculture, chemical engineering, nutrition, and foods.
Bioactive Delivery Systems for Lipophilic Nutraceuticals: Formulation, Fabrication, and Application, The Royal Society of Chemistry, 2023.
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Table of contents
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Chapter 1: Overview of Bioactive Delivery Systemsp1-11ByDavid Julian McClementsDavid Julian McClementsSearch for other works by this author on:
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Chapter 2: Lipophilic Nutraceuticalsp12-33ByYashu Chen;Yashu ChenOil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Hubei Key Laboratory of Lipid Chemistry and NutritionWuhanChina[email protected]Search for other works by this author on:Hongjian Chen;Hongjian ChenOil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Hubei Key Laboratory of Lipid Chemistry and NutritionWuhanChina[email protected]Search for other works by this author on:Qianchun Deng;Qianchun DengOil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Hubei Key Laboratory of Lipid Chemistry and NutritionWuhanChina[email protected]Search for other works by this author on:Long Chen;Long ChenSchool of Food Science and TechnologyJiangnan University, 1800 Lihu RoadWuxi214122ChinaSearch for other works by this author on:David Julian McClementsDavid Julian McClementsDepartment of Food ScienceUniversity of MassachusettsAmherstMA 01003USASearch for other works by this author on:
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Chapter 3: Materials for Bioactive Compound Delivery Systemsp34-83ByA. C. Aguiar;A. C. AguiarDepartment of Food Engineering and Technology (DETA), School of Food Engineering (FEA)University of Campinas (UNICAMP), Rua Monteiro Lobato, 80CampinasSP CEP: 13083-862Brazil[email protected]Search for other works by this author on:A. Gomes;A. GomesDepartment of Food Engineering, Faculty of Animal Science and Food EngineeringUniversity of São PauloPirassunungaSPBrazilFood Research Center (FoRC)University of São Paulo, Rua Do Lago, 250, Semi-industrial Building, Block C05508-080São PauloSPBrazilSearch for other works by this author on:A. L. R. Costa;A. L. R. CostaDepartment of Materials and Bioprocess Engineering, School of Chemical EngineeringUniversity of Campinas, Av. Albert Einstein, 500CampinasSP CEP: 13083-852BrazilSearch for other works by this author on:R. L. CunhaR. L. CunhaDepartment of Food Engineering and Technology (DETA), School of Food Engineering (FEA)University of Campinas (UNICAMP), Rua Monteiro Lobato, 80CampinasSP CEP: 13083-862Brazil[email protected]Search for other works by this author on:
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Chapter 4: Fabrication Methods for Bioactive Delivery Systemsp84-106ByHualu Zhou;Hualu ZhouBiopolymers and Colloids Laboratory, Department of Food ScienceUniversity of MassachusettsAmherstMA 01003USA[email protected]Search for other works by this author on:David Julian McClements;David Julian McClementsBiopolymers and Colloids Laboratory, Department of Food ScienceUniversity of MassachusettsAmherstMA 01003USA[email protected]Search for other works by this author on:Long ChenLong ChenState Key Laboratory of Food Science and Technology, School of Food Science and TechnologyJiangnan University, 1800 Lihu RoadWuxi214122ChinaSearch for other works by this author on:
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Chapter 5: Characterization Methodsp107-147BySarah Caballero;Sarah CaballeroDepartment of Nutrition and Food ScienceCalifornia State Polytechnic University, 3801 West Temple AvePomonaCA 91768USA[email protected]Search for other works by this author on:Juan Carlos Cuevas-Bernardino;Juan Carlos Cuevas-BernardinoCONACYT – Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Subsede Sureste, Parque Científico Tecnológico de Yucatánkm 5.5, Carretera Sierra Papacal – Chuburná Puerto97302MéridaYucatánMexicoSearch for other works by this author on:Gabriel Davidov-PardoGabriel Davidov-PardoDepartment of Nutrition and Food ScienceCalifornia State Polytechnic University, 3801 West Temple AvePomonaCA 91768USA[email protected]Search for other works by this author on:
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Chapter 6: Nanoemulsions and Emulsionsp148-180ByH. Zheng;H. ZhengDepartment of Plant SciencesNorth Dakota State UniversityFargoND 58102United States[email protected]School of Materials Science and EngineeringTongji UniversityShanghaiChinaSearch for other works by this author on:J. RaoJ. RaoDepartment of Plant SciencesNorth Dakota State UniversityFargoND 58102United States[email protected]Search for other works by this author on:
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Chapter 7: Pickering Emulsionsp181-206ByHan Wang;Han WangKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P.R. China[email protected][email protected]Search for other works by this author on:Siqi Huan;Siqi HuanKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P.R. China[email protected][email protected]Search for other works by this author on:Zhiguo Li;Zhiguo LiKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P.R. China[email protected][email protected]Search for other works by this author on:Yang Liu;Yang LiuKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P.R. China[email protected][email protected]Search for other works by this author on:Chuanling Si;Chuanling SiTianjin Key Laboratory of Pulp and PaperTianjin University of Science and TechnologyTianjin 300457P.R. ChinaSearch for other works by this author on:David Julian McClements;David Julian McClementsDepartment of Food ScienceUniversity of Massachusetts AmherstAmherstMassachusetts 01003USASearch for other works by this author on:Orlando J. Rojas;Orlando J. RojasBioproducts Institute, Departments of Chemical & Biological Engineering, Chemistry, and Wood ScienceThe University of British ColumbiaVancouverBritish Columbia V6T 1Z3CanadaSearch for other works by this author on:Shouxin Liu;Shouxin LiuKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P.R. China[email protected][email protected]Search for other works by this author on:Long BaiLong BaiKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P.R. China[email protected][email protected]Search for other works by this author on:
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Chapter 8: High Internal Phase Emulsionsp207-231ByKaiyue Wang;Kaiyue WangKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P. R. China[email protected][email protected]Search for other works by this author on:Rao Guo;Rao GuoKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P. R. China[email protected][email protected]Search for other works by this author on:Hao Li;Hao LiKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P. R. China[email protected][email protected]Search for other works by this author on:Long Bai;Long BaiKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P. R. China[email protected][email protected]Search for other works by this author on:David Julian McClements;David Julian McClementsDepartment of Food ScienceUniversity of MassachusettsAmherstMassachusetts 01003USASearch for other works by this author on:Orlando J. Rojas;Orlando J. RojasBioproducts Institute, Departments of Chemical & Biological Engineering, Chemistry, and Wood ScienceThe University of British ColumbiaVancouverBritish Columbia V6T 1Z3CanadaSearch for other works by this author on:Siqi Huan;Siqi HuanKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P. R. China[email protected][email protected]Search for other works by this author on:Chengyu WangChengyu WangKey Laboratory of Bio-based Material Science and Technology (Ministry of Education)Northeast Forestry UniversityHarbin 150040P. R. China[email protected][email protected]Search for other works by this author on:
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Chapter 9: Organogelsp232-266ByB. OzelB. OzelFood Engineering DepartmentAhi Evran University40100 KirsehirTurkeySearch for other works by this author on:
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Chapter 10: Liposomesp267-300ByMatheus A. Chaves;Matheus A. ChavesLaboratory of Encapsulation and Functional Foods, Food Engineering Department, School of Animal Science and Food EngineeringUniversity of São Paulo (USP)PirassunungaSPBrazil[email protected][email protected]Search for other works by this author on:Bruno S. Esposto;Bruno S. EspostoChemistry Department, Faculty of Philosophy, Sciences and Letters at Ribeirão PretoUniversity of São Paulo (USP)Ribeirão PretoSPBrazilSearch for other works by this author on:Milena Martelli-Tosi;Milena Martelli-TosiLaboratory of Encapsulation and Functional Foods, Food Engineering Department, School of Animal Science and Food EngineeringUniversity of São Paulo (USP)PirassunungaSPBrazil[email protected][email protected]Chemistry Department, Faculty of Philosophy, Sciences and Letters at Ribeirão PretoUniversity of São Paulo (USP)Ribeirão PretoSPBrazilSearch for other works by this author on:Samantha C. PinhoSamantha C. PinhoLaboratory of Encapsulation and Functional Foods, Food Engineering Department, School of Animal Science and Food EngineeringUniversity of São Paulo (USP)PirassunungaSPBrazil[email protected][email protected]Search for other works by this author on:
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Chapter 11: Nanocrystal-based Systemsp301-321ByShengfeng Peng;Shengfeng PengState Key Laboratory of Food Science and TechnologyNanchang UniversityNanchang 330047JiangxiPR China[email protected]Search for other works by this author on:David Julian McClements;David Julian McClementsBiopolymers and Colloids Laboratory, Department of Food ScienceUniversity of MassachusettsAmherstMA01003USASearch for other works by this author on:Long ChenLong ChenState Key Lab of Food Science and Technology, School of Food Science and TechnologyJiangnan University, 1800 Lihu RoadWuxi214122ChinaSearch for other works by this author on:
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Chapter 12: Phytoglycogen-based Systemsp322-346ByYaning Shi;Yaning ShiCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu210095P. R. ChinaState Key Laboratory of Food Science and TechnologyJiangnan University, 1800 Lihu AvenueWuxiJiangsu 214122P. R. China[email protected]Search for other works by this author on:Shilei Chen;Shilei ChenCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu210095P. R. ChinaSearch for other works by this author on:Hangyu Bai;Hangyu BaiCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu210095P. R. ChinaSearch for other works by this author on:Long Chen;Long ChenState Key Laboratory of Food Science and TechnologyJiangnan University, 1800 Lihu AvenueWuxiJiangsu 214122P. R. China[email protected]Search for other works by this author on:Ming MiaoMing MiaoState Key Laboratory of Food Science and TechnologyJiangnan University, 1800 Lihu AvenueWuxiJiangsu 214122P. R. China[email protected]Search for other works by this author on:
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Chapter 13: Highly Branched Cyclic Glucan-based Systemsp347-365ByMing Miao;Ming MiaoState Key Laboratory of Food Science & TechnologyJiangnan University, 1800 Lihu AvenueWuxiJiangsu Province 214122People's Republic of China[email protected]Search for other works by this author on:Yujing Sun;Yujing SunState Key Laboratory of Food Science & TechnologyJiangnan University, 1800 Lihu AvenueWuxiJiangsu Province 214122People's Republic of China[email protected]Search for other works by this author on:Chen Chen;Chen ChenState Key Laboratory of Food Science & TechnologyJiangnan University, 1800 Lihu AvenueWuxiJiangsu Province 214122People's Republic of China[email protected]Search for other works by this author on:Long ChenLong ChenState Key Laboratory of Food Science & TechnologyJiangnan University, 1800 Lihu AvenueWuxiJiangsu Province 214122People's Republic of China[email protected]Search for other works by this author on:
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Chapter 14: Nanostructured Protein-based Systemsp366-391ByShuai Chen;Shuai ChenSchool of Public HealthWuhan University, Donghu Road No. 115, Wuchang DistrictWuhan430071China[email protected]Search for other works by this author on:Yahong Han;Yahong HanCollege of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023ChinaSearch for other works by this author on:Suqing Wang;Suqing WangSchool of Public HealthWuhan University, Donghu Road No. 115, Wuchang DistrictWuhan430071China[email protected]Search for other works by this author on:Yangchao LuoYangchao LuoDepartment of Nutritional SciencesUniversity of ConnecticutStorrsCT06269USASearch for other works by this author on:
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Chapter 15: Nanofiber-based Systemsp392-420ByFei Liu;Fei LiuState Key Laboratory of Food Science and Technology, Science Center for Future Foods, School of Food Science and Technology, International Joint Laboratory on Food SafetyJiangnan UniversityWuxi 214122China[email protected]Search for other works by this author on:Yun Ma;Yun MaState Key Laboratory of Food Science and Technology, Science Center for Future Foods, School of Food Science and Technology, International Joint Laboratory on Food SafetyJiangnan UniversityWuxi 214122China[email protected]Search for other works by this author on:Furkan TürkerSaricaoğlu;Furkan TürkerSaricaoğluDepartment of Food Engineering, Faculty of Engineering and Natural SciencesBursa Technical UniversityYıldırım/Bursa 16310TurkeySearch for other works by this author on:Bor-Sen ChiouBor-Sen ChiouWestern Regional Research Center, ARS, U.S. Department of AgricultureAlbanyCalifornia 94710USASearch for other works by this author on:
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Chapter 16: Hydrogel-based Systemsp421-443ByLong Chen;Long ChenSchool of Food Science and TechnologyJiangnan University, 1800 Lihu RoadWuxi214122China[email protected][email protected]School of Food Science and TechnologySouth China Agricultural UniversityGuangzhou510642ChinaGuangdong Licheng Detection Technology Co., LtdZhongshan528436ChinaSearch for other works by this author on:Zhongyu Yang;Zhongyu YangSchool of Food Science and TechnologyJiangnan University, 1800 Lihu RoadWuxi214122China[email protected][email protected]Search for other works by this author on:David Julian McClements;David Julian McClementsDepartment of Food ScienceUniversity of MassachusettsAmherstMA01003USASearch for other works by this author on:Zipei Zhang;Zipei ZhangLaboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care MedicineBoston Children's Hospital, Harvard Medical SchoolBostonMA 02115USASearch for other works by this author on:Zhenlin Xu;Zhenlin XuSchool of Food Science and TechnologySouth China Agricultural UniversityGuangzhou510642ChinaSearch for other works by this author on:Man Meng;Man MengGuangdong Licheng Detection Technology Co., LtdZhongshan528436ChinaSearch for other works by this author on:Xinwen Peng;Xinwen PengState Key Laboratory of Pulp and Paper EngineeringSouth China University of TechnologyGuangzhou510640ChinaSearch for other works by this author on:Zhengyu JinZhengyu JinSchool of Food Science and TechnologyJiangnan University, 1800 Lihu RoadWuxi214122China[email protected][email protected]Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu ProvinceJiangnan University, 1800 Lihu RoadWuxi214122ChinaSearch for other works by this author on:
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Chapter 17: Self-assembled Nanoparticle-based Systemsp444-476ByFuguo Liu;Fuguo LiuCollege of Food Science and EngineeringNorthwest A&F UniversityYangling 712100ShaanxiPR China[email protected]Search for other works by this author on:Xiuping Liang;Xiuping LiangCollege of Food Science and EngineeringNorthwest A&F UniversityYangling 712100ShaanxiPR China[email protected]Search for other works by this author on:Xueqi Li;Xueqi LiCollege of Food Science and EngineeringNorthwest A&F UniversityYangling 712100ShaanxiPR China[email protected]Search for other works by this author on:Zhaowei JiangZhaowei JiangCollege of Food Science and EngineeringNorthwest A&F UniversityYangling 712100ShaanxiPR China[email protected]Search for other works by this author on:
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Chapter 18: Next-generation Bioactive Delivery Systemsp477-498ByDavid Julian McClementsDavid Julian McClementsSearch for other works by this author on:
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