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Separation and preconcentration of organic and inorganic analytes from food and environmental samples requires sample preparation methods based on solid and liquid phase extraction techniques. Studies in which metal–organic frameworks (MOFs) have been used as adsorbents in sample preparation steps in solid phase extraction (SPE) for trace determination of these analytes for food safety and environmental health are discussed. Due to their excellent properties such as adsorption capacity, chemical and thermal stability, and easy functionalization, MOFs have been used in various studies for the detection and removal of pesticides, drugs, and dyes (organic pollutants) and toxic metals (inorganic pollutants) from food and environmental matrices, and the separation techniques and detection methods used in these studies are explained. Thus, this chapter will shed light on the development of new materials and making different techniques more effective.

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