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In this chapter, we present an overview of graphene derivatives and their nanocomposites for the development of biosensors. The importance of graphene nanocomposites in sensing is also highlighted. They have received much attention due to their distinctive chemical and physical properties. The surface, mechanical, optical, thermal, electronic, and other properties of graphene are also reviewed. Additionally, some graphene derivatives, such as GO and rGO, are described. Some common synthesis methods of graphene by top-down and bottom-up approaches, including mechanical exfoliation, chemical synthesis, chemical vapor deposition, pyrolysis, and other methods, are summarized. Finally, the chapter focuses on some applications of graphene nanocomposite-modified electrodes in sensing applications.

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